Ultrasound-targeted nucleic acid delivery for solid tumor therapy.
Ultrasound-targeted nucleic acid delivery for solid tumor therapy.
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DOI：
10.1016/j.jconrel.2021.10.010
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发表时间：
2021-11-10
期刊：
影响因子：
--
通讯作者：
Price RJ
中科院分区：
文献类型：
--
作者：
Schwartz MR;Debski AC;Price RJ
根据多种因素，恶性实体瘤通常采用手术切除、放疗、化疗和免疫治疗的组合治疗。尽管经过了几十年的研究，许多癌症适应症的治疗效果仍然很差。此外，我们目前的许多治疗方法要么是侵入性的，要么伴有毒副作用。代替传统药物和侵入性治疗干预，基因疗法为新的抗癌疗法提供了更灵活、更持久的方法。然而，由于生理障碍限制了遗传物质的外渗和吸收，许多目前的基因传递方法存在转染效率低的问题。此外，系统给药的基因疗法可能缺乏目标特异性，这可能导致脱靶效应。为了克服这些挑战，许多临床前研究表明，聚焦超声（FUS）在图像引导下可以增加细胞和组织中的大分子摄取，这表明了改善实体肿瘤治疗方法的前景。基于fus的药物递送目前正在世界各地的几个临床试验中进行测试，以fus为目标的实体肿瘤基因治疗可能不会落后。在这篇综述中，我们全面涵盖了与临床前尝试更有效地传递FUS治疗性遗传物质有关的文献，并为未来的研究和临床翻译提供了展望。
Depending upon multiple factors, malignant solid tumors are conventionally treated by some combination of surgical resection, radiation, chemotherapy, and immunotherapy. Despite decades of research, therapeutic responses remain poor for many cancer indications. Further, many current therapies in our armamentarium are either invasive or accompanied by toxic side effects. In lieu of traditional pharmaceutics and invasive therapeutic interventions, gene therapies offer more flexible and potentially more durable approaches for new anti-cancer therapies. Nonetheless, many current gene delivery approaches suffer from low transfection efficiency due to physiological barriers limiting extravasation and uptake of genetic material. Additionally, systemically administered gene therapies may lack target-specificity, which can lead to off-target effects. To overcome these challenges, many preclinical studies have shown the utility of focused ultrasound (FUS) to increase macromolecule uptake in cells and tissue under image guidance, demonstrating promise for improved delivery of therapeutics to solid tumors. As FUS-based drug delivery is now being tested in several clinical trials around the world, FUS-targeted gene therapy for solid tumor therapy may not be far behind. In this review, we comprehensively cover the literature pertaining to preclinical attempts to more efficiently deliver therapeutic genetic material with FUS and offer perspectives for future studies and clinical translation.
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影响因子：
10.8
作者：
Chang, En-Ling;Ting, Chien-Yu;Yeh, Chih-Kuang
通讯作者：
Yeh, Chih-Kuang
影响因子：
9.5
作者：
Dwivedi, Pankaj;Kiran, Sonia;Xu, Ronald
通讯作者：
Xu, Ronald
分子机制和血管生成的临床应用。
影响因子：
64.8
作者：
Carmeliet, Peter;Jain, Rakesh K.
通讯作者：
Jain, Rakesh K.
影响因子：
1.9
作者：
Glimelius, Bengt;Cavalli-Bjorkman, Nina
通讯作者：
Cavalli-Bjorkman, Nina
DOI：
10.1016/j.jconrel.2010.06.012
发表时间：
2010-11-20
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Böhmer MR;Chlon CHT;Raju BI;Chin CT;Shevchenko T;Klibanov AL
通讯作者：
Klibanov AL