Chronic unpredictable stress inhibits nociception in male rats
Chronic unpredictable stress inhibits nociception in male rats
复制标题
DOI：
10.1016/j.neulet.2004.02.016
复制
发表时间：
2004-04-08
影响因子：
2.5
通讯作者：
Sousa, N
中科院分区：
文献类型：
--
作者：
Pinto-Ribeiro, F;Almeida, A;Sousa, N
慢性应激可引起中枢神经系统多个区域的结构和功能发生显著改变。已知伤害感受受慢性压力和年龄的影响，尽管观察结果是矛盾的。在此，我们报告说，年轻和老年大鼠提交了一个慢性不可预测的压力范例减少了甩尾伤害性试验中的伤害性感受。此外，应激动物在连续三次暴露于伤害性刺激（在2分钟间隔内）后显示伤害性阈值的增加。虽然持续的应激诱导的镇痛通常归因于由此产生的皮质机能亢进，但由于观察到的非常快速的抗伤害效应，应激动物对疼痛的耐受性的立即加剧最有可能通过其他机制介导。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Chronic stress elicits remarkable alterations to the structure and function of several areas of the central nervous system. Nociception is known to be affected by chronic stress and age, although the observations are contradictory. Herein we report that both young and old rats submitted to a chronic unpredictable stress paradigm have reduced nociception in the tail-flick nociceptive test. Moreover, stressed animals show an increase in nociceptive threshold after three successive exposures to noxious stimulation (within a 2 min interval). While the sustained stress-induced analgesia is usually attributed to the resulting hypercorticalism, the immediate exacerbation of tolerance to pain displayed by stressed animals is most likely mediated through other mechanisms due to the very rapid antinociceptive effect observed. (C) 2004 Elsevier Ireland Ltd. All rights reserved.