Seasonal fluctuation in intraocular pressure and its associated factors in primary open-angle glaucoma
Seasonal fluctuation in intraocular pressure and its associated factors in primary open-angle glaucoma
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DOI：
10.1038/s41433-021-01403-6
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发表时间：
2021-02
期刊：
影响因子：
3.9
通讯作者：
Ryo Terauchi;S. Ogawa;Akiko Sotozono;Takahiko Noro;M. Tatemichi;T. Nakano
中科院分区：
文献类型：
--
作者：
Ryo Terauchi;S. Ogawa;Akiko Sotozono;Takahiko Noro;M. Tatemichi;T. Nakano
目的探讨原发性开角型青光眼（primary open-angle glaucoma，POAG）眼内压（intraocular pressure，IOP）的季节性波动及其相关因素。评估冬季和夏季IOP。眼压的季节波动率定义为：（冬季平均眼压-夏季平均眼压）/各季节平均眼压。采用多元线性回归分析探索与季节性IOP波动率相关的因素，包括：年龄、性别、青光眼家族史、青光眼类型、滴眼次数、滴眼液类型、平均偏差（MD）值、MD斜率、视盘出血、中央角膜厚度和等效球镜。其中正常眼压性青光眼（NTG）162眼（13.2 ± 2.7vs.12.0 ± 2.3mmHg，P< 0.001）。平均年龄和随访时间分别为63.3 ± 11.4岁和140.0 ± 66.9个月。初始MD和MD斜率分别为−2.1 ± 3.4 dB和−0.07 ± 0.50 dB/年。与NTG相比，POAG与季节性眼压波动率呈正相关（β= 5.29，P = 0.013）。家族史、噻吗洛尔和卡替洛尔的使用也是与IOP波动率相关的因素（分别为β=-6.27，P = 0.007;β= 4.94，P = 0.030;和β= 4.51，P = 0.042）。青光眼类型、青光眼家族史和β受体阻滞剂的使用可能影响IOP波动。
Background/ObjectivesTo evaluate seasonal fluctuations in intraocular pressure (IOP) in primary open-angle glaucoma (POAG) and its associated factors.Subjects/MethodsPOAG patients treated only with glaucoma eye drops were enroled. Winter and summer IOPs were evaluated. The Seasonal fluctuation rate of IOP was defined as follows: (mean winter IOP—mean summer IOP)/mean IOP in all seasons. Multiple linear regression analysis was used to explore factors associated with the seasonal IOP fluctuation rate including: age, gender, family history of glaucoma, type of glaucoma, number of eye drops, type of eye drops, mean deviation (MD) value, MD slope, disc haemorrhage, central corneal thickness and spherical equivalent.ResultsWinter IOP was higher than summer IOP in 204 POAG eyes of 204 patients, including 162 eyes with normal tension glaucoma (NTG) (13.2 ± 2.7 vs. 12.0 ± 2.3 mmHg,P< 0.001). The mean age and follow-up duration were 63.3 ± 11.4 years and 140.0 ± 66.9 months. Initial MD and MD slope were −2.1 ± 3.4 dB and −0.07 ± 0.50 dB/year, respectively. POAG was positively associated with the rate of seasonal IOP fluctuations compared to NTG (β= 5.29,P= 0.013). Family history, and timolol and carteolol use were also factors associated with the IOP fluctuation rate (β= −6.27,P= 0.007;β= 4.94, P = 0.030; andβ= 4.51,P= 0.042, respectively).ConclusionsWe confirmed seasonal IOP fluctuations in POAG. Type of glaucoma, family history of glaucoma, and β-blocker use might influence IOP fluctuations.