Incremental contribution of reported previous head injury to the prediction of diagnosis and cognitive functioning in older adults
Incremental contribution of reported previous head injury to the prediction of diagnosis and cognitive functioning in older adults
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DOI：
10.3109/02699052.2011.556104
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发表时间：
2011-04-01
期刊：
影响因子：
1.9
通讯作者：
Steenhuis, Runa E.
中科院分区：
文献类型：
--
作者：
Helmes, Edward;Ostbye, Truls;Steenhuis, Runa E.
背景：严重的脑损伤可能是晚年患痴呆症的危险因素。相对较短甚至没有意识丧失的不太严重的事件可能不会带来相同的预后。 目的：本研究使用加拿大健康与老龄化研究前两波（CSHA-1 和 CSHA-2）的数据来调查两个问题。 (1) 头部外伤史是否可以提高痴呆诊断的预测率？这项分析基于 921 名老年人，他们在 CSHA-2 中接受了临床评估，并在 5 年前报告了他们是否患有头部损伤。 (2) 添加有关头部受伤史的信息是否可以改善神经心理学测试分数的预测？第二次分析纳入了 585 名老年人，他们在两次浪潮中都接受了神经心理学评估，并报告了自己是否有轻度或中度至重度头部损伤的病史。 结果：结果显示，纳入头部损伤信息并没有改善痴呆症诊断结果的预测。年龄和整体认知状态与大多数神经心理学测试分数相关，比慢性健康问题的影响更有限，后者与大约一半的神经心理学测量相关。
Background: Severe brain injuries may be a risk factor for the development of dementia in later life. Less severe incidents with relatively short or even no loss of consciousness may not carry the same prognosis.Objectives: This study used data from the first two waves of the Canadian Study of Health and Ageing (CSHA-1 and CSHA-2) to investigate two questions. (1) Does a history of head injury improve the prediction of the diagnosis of dementia? This analysis was based on the 921 elderly individuals who underwent a clinical assessment in CSHA-2 and, 5 years earlier, had reported whether or not they had had a head injury. (2) Does adding information about a history of head injury improve the prediction of neuropsychological test scores? This second analysis included 585 elderly people who underwent neuropsychological assessment in both waves and who also reported whether or not they had had a history of mild or moderate-to-severe head injury.Results: Results showed that the inclusion of head injury information did not improve the prediction of diagnostic outcome of dementia. Age and overall cognitive status were associated with most neuropsychological test scores, more so than the more limited influence of chronic health problems, which was associated with about half of the neuropsychological measures.