The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.
The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.
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DOI：
10.1016/s2213-2600(21)00286-1
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
International COVID-19 Airways Diseases Group
中科院分区：
文献类型：
--
作者：
Adeloye D;Elneima O;Daines L;Poinasamy K;Quint JK;Walker S;Brightling CE;Siddiqui S;Hurst JR;Chalmers JD;Pfeffer PE;Novotny P;Drake TM;Heaney LG;Rudan I;Sheikh A;De Soyza A;International COVID-19 Airways Diseases Group
急性COVID-19后的持续健康状况不佳-被称为长期COVID、急性COVID-19后综合征或COVID-19后状况-已成为一个主要问题。我们进行了一项国际共识活动，以确定研究优先事项，旨在了解急性COVID-19的长期影响，重点关注既存气道疾病的人群以及新发气道疾病和相关症状的发生。202名国际专家被邀请提交至少三个研究想法。经过两个阶段的内部审查过程，最终由48名专家对98个研究课题进行了评分。通过对选定标准进行加权，患有先前存在或COVID-19后气道疾病的患者参与了这项工作。排名最高的研究思路侧重于调查有和无既存气道疾病的患者入院时的预后评分与出院后3个月和12个月的发病率之间的关系。此外，还优先考虑了在有和没有既存气道疾病的患者中比较COVID-19后疲劳、肌肉减少症、焦虑、抑郁以及未来心血管并发症风险的患病率和严重程度。我们的方法使一系列优先事项的发展，可以为未来的研究和资助决策提供信息。这一优先排序过程也可以适用于长期COVID的其他非呼吸方面。
Persistent ill health after acute COVID-19—referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition—has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.
影响因子：
15.8
作者：
Fontaine O;Kosek M;Bhatnagar S;Boschi-Pinto C;Chan KY;Duggan C;Martinez H;Ribeiro H;Rollins NC;Salam MA;Santosham M;Snyder JD;Tsai AC;Vargas B;Rudan I
通讯作者：
Rudan I