Distinct spatiotemporal mechanisms underlie extra-classical receptive field modulation in macaque V1 microcircuits
Distinct spatiotemporal mechanisms underlie extra-classical receptive field modulation in macaque V1 microcircuits
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DOI：
10.7554/elife.54264
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发表时间：
2020-05-27
期刊：
影响因子：
7.7
通讯作者：
Hawken, Michael J.
中科院分区：
文献类型：
--
作者：
Henry, Christopher A.;Jazayeri, Mehrdad;Hawken, Michael J.
复杂场景感知依赖于初级视觉皮层（V1）神经元中经典感受野（CRF）和超经典感受野（eCRF）信号的相互作用。尽管我们对V1 eCRF的特性了解很多，但我们还不知道其潜在机制是如何映射到皮层微电路上的。我们使用反向相关范式探讨了eCRF调制的时空动态，发现了三种主要的eCRF机制：调谐-促进、非调谐-抑制和调谐-抑制。每种机制都有不同的时间和空间轮廓。层流分析表明，eCRF机制的时序、定向调谐和强度在V1微电路的大细胞和微细胞加工流中具有不同的特征。多种eCRF机制的存在为V1如何响应空间环境提供了新的见解。模型显示，这些机制在时间和规模上的差异预测了净调节的不同模式，这与许多先前不同的生理和心理物理发现相吻合。
Complex scene perception depends upon the interaction between signals from the classical receptive field (CRF) and the extra-classical receptive field (eCRF) in primary visual cortex (V1) neurons. Although much is known about V1 eCRF properties, we do not yet know how the underlying mechanisms map onto the cortical microcircuit. We probed the spatio-temporal dynamics of eCRF modulation using a reverse correlation paradigm, and found three principal eCRF mechanisms: tuned-facilitation, untuned-suppression, and tuned-suppression. Each mechanism had a distinct timing and spatial profile. Laminar analysis showed that the timing, orientation-tuning, and strength of eCRF mechanisms had distinct signatures within magnocellular and parvocellular processing streams in the V1 microcircuit. The existence of multiple eCRF mechanisms provides new insights into how V1 responds to spatial context. Modeling revealed that the differences in timing and scale of these mechanisms predicted distinct patterns of net modulation, reconciling many previous disparate physiological and psychophysical findings.