Investigation of parallel and simultaneous selection for collie eye anomaly and ivermectin toxicosis.
Investigation of parallel and simultaneous selection for collie eye anomaly and ivermectin toxicosis.
复制标题
牧羊犬眼睛异常和伊维菌素中毒的平行和同时选择的研究。
DOI：
10.1136/vr.102015
复制
发表时间：
2014
影响因子：
2.2
通讯作者：
Yamato O.
中科院分区：
文献类型：
--
作者：
Mizukami K;Yabuki A;Endoh D;Chang HS;Lee KW;Nakayama M;Kushida K;Kohyama M;Lee JI;Yamato O.
牧羊犬眼异常（CeA）是一种遗传性犬眼部疾病，可引起视盘或邻近区域的局部脉络膜发育不全和缺损，与犬NHEJ 1基因中7.8千碱基对（bp）缺失相关（帕克等人，2007）。在给予P-糖蛋白底物（如伊维菌素）后，犬MDR 1/ABCB 1基因中的4-bp缺失（MDR 1基因缺陷）导致神经中毒（Gramer等人，2011）。这两种突变在与牧羊犬相关的犬种和猎犬品种中很常见，这表明这两种缺陷可能是平行选择的，尽管这些犬基因位于不同的染色体上：37号染色体上的NHEJ 1和14号染色体上的MDR 1（帕克等人2007，格拉默等人2011）。最近，在北海道因纽特人中报道了非常高频率的CeA突变，一种传统的日本品种;这是第一次发现CeA易感品种，而不是归类为牧羊犬或观光犬（Mizukami等人，2012 a）。一个日本本土品种，柴犬，以前曾在多品种聚类分析（帕克和其他人2007年）中定位于牧羊犬附近，这表明牧羊犬和这些亚洲本土品种共享更多的遗传特征，
Collie eye anomaly (CeA) is an inherited canine ocular disorder causing regional choroidal hypoplasia and coloboma of the optic disk or adjacent areas, and is associated with a 7.8-kilo base pair (bp) deletion in the canine NHEJ1 gene (Parker and others 2007). A 4-bp deletion in the canine MDR1/ABCB1 gene (MDR1 gene defect) causes neurotoxicosis after administration of P-glycoprotein substrates such as ivermectin (Gramer and others 2011). These two mutations are common in collie-related and sighthound breeds, suggesting a possible parallel selection of the two defects, although these canine genes are located on different chromosomes: NHEJ1 on chromosome 37 and MDR1 on chromosome 14 (Parker and others 2007, Gramer and others 2011).Recently, a very high frequency of the CeA mutation has been reported in the Hokkaido inu, a traditional Japanese breed; this is the first identification of a CeA-predisposed breed not classified as collies or sighthounds (Mizukami and others 2012a). A native Japanese breed, the shiba inu, has been previously localised near collies in multibreed cluster analyses (Parker and others 2007), suggesting that collies and such native Asian breeds share more genetic traits than