GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.
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DOI：
10.1038/srep43395
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发表时间：
2017-03-06
影响因子：
4.6
通讯作者：
Spiropoulou CF
中科院分区：
文献类型：
--
作者：
Lo MK;Jordan R;Arvey A;Sudhamsu J;Shrivastava-Ranjan P;Hotard AL;Flint M;McMullan LK;Siegel D;Clarke MO;Mackman RL;Hui HC;Perron M;Ray AS;Cihlar T;Nichol ST;Spiropoulou CF
GS-5734 是腺苷核苷类似物的单磷酸前药，在埃博拉病毒感染的非人灵长类动物模型中显示出治疗效果。该药物已在同情用药的情况下对两名埃博拉患者进行了治疗，两人都幸存下来，目前正处于治疗埃博拉病毒病的二期临床开发阶段。在此，我们报告了 GS-5734 及其母体核苷类似物在多个病毒家族中的抗病毒活性，为支持该化合物针对具有重大公共卫生问题的人类病毒的新适应症提供了证据。
GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development for treatment of Ebola virus disease. Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new indications for this compound against human viruses of significant public health concern.