Handedness and mortality: A follow-up study of Danish twins born between 1900 and 1910
Handedness and mortality: A follow-up study of Danish twins born between 1900 and 1910
复制标题
DOI：
10.1097/00001648-200009000-00014
复制
发表时间：
2000-09-01
期刊：
影响因子：
5.4
通讯作者：
Christensen, K
中科院分区：
文献类型：
--
作者：
Basso, O;Olsen, J;Christensen, K
随着年龄的增长，左撇子的患病率不断下降，这导致了两种主要的假设途径：这种关联是由于（1）出生群体效应和/或随着年龄的增长而转向右手所引起的年龄效应，或（2）死亡率选择降低了左撇子个体的生存率，或两者兼而有之。目前还不确定队列效应或年龄效应是否可以解释与年龄相关的患病率的下降，并且存在支持死亡率假设的相互矛盾的证据。我们通过计算右利手双胞胎先死亡的情况来比较 118 对左右利手双胞胎的死亡率。在整个 1900-1910 年队列中，没有证据表明右手和非右手个体之间存在生存差异。就先死亡的右利手双胞胎的数量而言，非右利手双胞胎并没有实质性的劣势。在 60%（95% 置信区间 = 49.0-71.5%）的异卵双胞胎中，右手双胞胎首先死亡。在 50% 的同卵双胞胎中，右利手双胞胎首先死亡。男性非右利手比例（9.2%）高于女性（6.5%）；在同卵双胞胎（8.0%）和异卵双胞胎（7.8%）中，非右利手的频率相似。在这项后续研究中，我们没有发现非右撇子成年双胞胎死亡率过高的证据。
The declining prevalence of left-handed individuals with increasing age has led to two main avenues of hypotheses; the association is due either (1) to a birth cohort effect and/or an age effect caused by a switch to right-handedness with advancing age or (2) to mortality selection that reduces survival in left-handed individuals, or both. It is uncertain whether a cohort or age effect can explain the decline in age-related prevalence, and conflicting evidence exists in favor of the mortality hypothesis. We compared mortality in a subgroup of 118 opposite handed twin pairs by counting in how many instances the right-handed twin died first. There was no evidence of differential survival between right-handed and non-right handed individuals in the entire 1900-1910 cohort. With respect to the number of right-handed twins who died first, there was no material disadvantage among those who were not right-handed. In 60% (95% confidence interval = 49.0-71.5%) of dizygotic pairs, the right-handed twins died first. In 50% of monozygotic pairs, right-handed twins died first. The prevalence of not being right handed was higher among males (9.2%) than females (6.5%); there was a similar frequency of non right-handedness in monozygotic (8.0%) and dizygotic (7.8%) twins. We did not find evidence of excess mortality among non-right-handed adult twins in this follow up study.