Potential mechanisms of photopheresis in hematopoietic stem cell transplantation.
Potential mechanisms of photopheresis in hematopoietic stem cell transplantation.
复制标题
光去除术在造血干细胞移植中的潜在机制。
DOI：
10.1016/j.bbmt.2005.11.005
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
D. Peritt
中科院分区：
文献类型：
--
作者：
D. Peritt
免疫耐受描述了对抗原的特异性无反应性。在临床情况下，如移植物抗宿主病，利用这些预先存在的耐受机制来治疗患者可能是有用的。体外白细胞去除术是一种去除治疗，其中约5 × 109个白细胞用光活化化合物（8-甲氧基补骨脂素）和UVA光处理，并立即返回到患者的闭环，患者连接系统。这种疗法诱导几乎所有治疗的白细胞凋亡。有越来越多的证据表明，输注凋亡细胞可能会触发某些耐受机制，因此，在移植物抗宿主病的治疗用途。这些凋亡细胞被患者体内的吞噬细胞（抗原呈递细胞）摄取。据报道，凋亡细胞参与诱导吞噬抗原呈递细胞的几种变化和功能活动。这些抗原呈递细胞：（1）减少促炎细胞因子的产生;（2）增加抗炎细胞因子的产生;（3）降低刺激T细胞应答的能力;（4）删除CD 8 T效应细胞;和（5）诱导调节性T细胞。所有这些机制都可以解释移植物抗宿主病中的显著效应。目前还不清楚哪一个或哪几个真正负责。正在进行的动物研究和人体试验将最终揭开这些细节。
Immune tolerance describes specific unresponsiveness to antigens. In clinical situations such as graft-versus-host disease it may be useful to capitalize on these pre-existing tolerance mechanisms to treat patients. Extracorporeal photopheresis is a pheresis treatment whereby the approximately 5 × 109leukocytes are treated with a photoactivatable compound (8-methoxypsoralen) and UVA light, and immediately returned to the patient in a closed-loop, patient-connected system. This therapy induces apoptosis of virtually all the treated leukocytes. There is growing evidence that infusion of apoptotic cells may trigger certain tolerance mechanisms and, thus, be of therapeutic use in graft-versus-host disease. These apoptotic cells are taken up by phagocytes (antigen-presenting cells) in the body of the patient. Apoptotic cell engagement has been reported to induce several changes and functional activities in the engulfing antigen-presenting cell. These antigen-presenting cells: (1) decrease production of proinflammatory cytokines; (2) increase production of anti-inflammatory cytokines; (3) lower ability to stimulate T-cell responses; (4) delete CD8 T effector cells; and (5) induce regulatory T cells. Any and all of these mechanisms could explain the noted effect in graft-versus-host disease. It is still unclear which one or ones are truly responsible. Ongoing studies in animals and human trials will ultimately unravel these details.
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影响因子：
15.9
作者：
Fadok, VA;Bratton, DL;Henson, PM
通讯作者：
Henson, PM
影响因子：
20.3
作者：
Taylor, PA;Lees, CJ;Blazar, BR
通讯作者：
Blazar, BR
DOI：
10.1073/pnas.0400810101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Peng, YF;Laouar, Y;Flavell, RA
通讯作者：
Flavell, RA
影响因子：
20.3
作者：
Morelli, AE;Larregina, AT;Thomson, AW
通讯作者：
Thomson, AW
影响因子：
15.9
作者：
Huynh, MLN;Fadok, VA;Henson, PM
通讯作者：
Henson, PM