One Shoot, Two Birds: Alleviating Inflammation Caused by Ischemia/Reperfusion Injury to Reduce the Recurrence of Hepatocellular Carcinoma.
One Shoot, Two Birds: Alleviating Inflammation Caused by Ischemia/Reperfusion Injury to Reduce the Recurrence of Hepatocellular Carcinoma.
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一只芽，两只鸟：减轻缺血/再灌注损伤引起的炎症，以减少肝细胞癌的复发。
DOI：
10.3389/fimmu.2022.879552
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
炎症在肿瘤的发生和转移的发展中起着至关重要的作用。肝脏缺血再灌注损伤(IRI)是肝脏切除和移植中一个尚未解决的问题，它往往建立和重塑肝脏的炎性微环境。越来越多的实验和临床证据揭示了肝脏IRI及其相关炎症在促进肝细胞癌(HCC)复发中的作用。同时，针对减轻肝脏IRI的方法，如机器灌流，调节肠肝轴，靶向关键炎症成分，已被证明可以防止肝细胞癌复发。这篇综述文章重点介绍了通过减轻肝脏IRI引起的炎症来减少肿瘤复发的潜在机制和有前景的治疗策略。
Inflammation is crucial to tumorigenesis and the development of metastasis. Hepatic ischemia/reperfusion injury (IRI) is an unresolved problem in liver resection and transplantation which often establishes and remodels the inflammatory microenvironment in liver. More and more experimental and clinical evidence unmasks the role of hepatic IRI and associated inflammation in promoting the recurrence of hepatocellular carcinoma (HCC). Meanwhile, approaches aimed at alleviating hepatic IRI, such as machine perfusion, regulating the gut-liver axis, and targeting key inflammatory components, have been proved to prevent HCC recurrence. This review article highlights the underlying mechanisms and promising therapeutic strategies to reduce tumor recurrence through alleviating inflammation induced by hepatic IRI.
影响因子：
3.8
作者：
Li CX;Wong BL;Ling CC;Ma YY;Shao Y;Geng W;Qi X;Lau SH;Kwok SY;Wei N;Tzang FC;Ng KT;Liu XB;Lo CM;Man K
通讯作者：
Man K