Local and global motion after-effects are both enhanced in migraine, and the underlying mechanisms differ across cortical areas.
Local and global motion after-effects are both enhanced in migraine, and the underlying mechanisms differ across cortical areas.
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偏头痛时局部和整体运动后遗症都会增强，而且不同皮质区域的潜在机制有所不同。
DOI：
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
A. Shepherd
中科院分区：
文献类型：
--
作者：
A. Shepherd
视觉后效是长时间观看视觉显示(模式适应)后出现的错觉。例如，运动后效(MAE)是观看运动显示后看到的运动的虚幻印象。后遗症已被广泛应用于基础视力研究和临床环境中，并已被报道在偏头痛中得到增强。模式适应是一种皮层现象，它既反映了单个神经元内部的细胞机制，也反映了由适应显示激活的神经元组之间的特定相互作用。MAE的一个显著特征是，如果在适配结束和测试显示(存储)之间插入延迟，则其持续时间仅略微减少。减少与蜂窝组件的恢复一致，并且与在延迟期间保持的网络变化的剩余一致。这项研究的目的是(I)通过使用存储来梳理提出的适应的细胞和网络部分，来评估偏头痛延长的MAES的解释；(Ii)使用反映视觉系统不同阶段适应的局部和整体MAE来确定偏头痛皮质异常的程度。50名偏头痛(22名有先兆，28名没有先兆)和50名对照组参与者在观看静态或动态(随机运动)测试之前适应了运动，结果似乎是朝着相反的方向移动(分别是局部和全局MAE)。一半的试验包括改编和测试展示之间的延迟。这一结果扩展了先前报道的结果，因为与对照组相比，偏头痛的局部和全球MAE持续时间更长。两组患者的整体MAE几乎完全存活，而局部MAE在偏头痛中减少的程度更大。根据有无视觉先兆进行分类的偏头痛亚组之间没有显著差异。这些结果表明，偏头痛的细胞恢复在早期减缓，而不是在晚期视觉皮质区域。适应后持续的网络变化牵涉到大脑皮层区域。偏头痛患者和非偏头痛患者在各种视觉感知指标上的差异被归因于偏头痛患者大脑皮质处理的异常，表现为过度兴奋、反应增强和/或缺乏皮质内抑制。结果与偏头痛缺乏抑制导致的过度兴奋性不一致，但与皮质内兴奋的广泛抑制一致。讨论了这些结果对其他超兴奋性模型的影响。
Visual after-effects are illusions that occur after prolonged viewing of visual displays (pattern adaptation). The motion after-effect (MAE), for example, is an illusory impression of motion that is seen after viewing moving displays. After-effects have been used extensively in basic vision research as well as in clinical settings, and have been reported to be enhanced in migraine. Pattern adaptation is a cortical phenomenon that reflects both cellular mechanisms acting within individual neurons and specific interactions between groups of neurons activated by the adapting display. A remarkable feature of the MAE is that its duration is only slightly reduced if a delay is inserted between the end of the adaptation and the test display ('storage'). The reduction is consistent with recovery of the cellular component, and the residual with network changes that are maintained during the delay. This study aimed (i) to assess explanations for prolonged MAEs in migraine by teasing apart the proposed cellular and network components of adaptation using storage; (ii) to determine the extent of cortical abnormality in migraine using local and global MAEs, which reflect adaptation at different stages of the visual system. Fifty migraine (22 with, 28 without aura) and 50 control participants adapted to motion before viewing a stationary or dynamic (random motion) test, which consequently appeared to move in the opposite direction (local and global MAEs, respectively). Half of the trials included a delay between the adapting and test displays. The results extend those reported previously, as both local and global MAEs lasted longer in migraine compared with the control group. Global MAEs survived delays almost completely for both groups, whereas local MAEs were reduced to a greater extent in migraine. There were no significant differences between migraine subgroups classified according to the presence or absence of visual aura. These results suggest that cellular recovery is slowed in migraine for early but not later visual cortical areas. Sustained network changes following adaptation are implicated across cortical areas. Differences between people with and without migraine on various measures of visual perception have been attributed to abnormal cortical processing in migraine, variously described by hyperexcitability, heightened responsiveness and/or a lack of intra-cortical inhibition. The results are not consistent with hyperexcitability resulting from a lack of inhibition in migraine, but are consistent with extended suppression of intra-cortical excitation. The implications of these results for alternative models of hyperexcitability are discussed.
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DOI：
10.1073/pnas.89.19.9025
发表时间：
1992-10-01
影响因子：
11.1
作者：
HIRIS, E;BLAKE, R
通讯作者：
BLAKE, R
影响因子：
2.5
作者：
R. van Wezel;K. H. Britten
通讯作者：
R. van Wezel;K. H. Britten
影响因子：
2.5
作者：
Priebe, NJ;Churchland, MM;Lisberger, SG
通讯作者：
Lisberger, SG
影响因子：
56.9
作者：
Carandini, M;Ferster, D
通讯作者：
Ferster, D