Synthesis of functionalized indolizines via copper-catalyzed annulation of 2-alkylazaarenes with α,β-unsaturated carboxylic acids.
Synthesis of functionalized indolizines via copper-catalyzed annulation of 2-alkylazaarenes with α,β-unsaturated carboxylic acids.
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DOI：
10.1021/ol300067h
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发表时间：
2012-02
期刊：
影响因子：
5.2
通讯作者：
Yuzhu Yang;Chunsong Xie;Yong-Qiang Xie;Yuhong Zhang
中科院分区：
文献类型：
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作者：
Yuzhu Yang;Chunsong Xie;Yong-Qiang Xie;Yuhong Zhang
研究了铜催化下2-烷基氮杂芳烃与α，β-不饱和羧酸的环化反应。该反应以C-H烯化和脱羧胺化过程为特征，提供了从简单且容易获得的起始原料制备C-2芳基化中氮茚的简明途径。
A novel copper-catalyzed annulation of 2-alkylazaarenes with α,β-unsaturated carboxylic acids has been accomplished. This reaction featuring C-H olefination and decarboxylative amination processes provides a concise access to C-2 arylated indolizines from simple and readily available starting materials.