Developmental neuropathology of the second half of gestation
Developmental neuropathology of the second half of gestation
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DOI：
10.1016/j.earlhumdev.2005.01.005
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发表时间：
2005-03-01
影响因子：
2.5
通讯作者：
Gomez, IG
中科院分区：
文献类型：
--
作者：
Gilles, FH;Gomez, IG
在这篇综述中，我们主要关注发生在妊娠后半期的事件。在妊娠中期结束时，人类大脑的体重增加迅速加速。生发基质达到最大的绝对体积，仅在两个妊娠周内消融50%。在妊娠10周时，出现了半球间裂、脉络膜裂和横向裂。生发性基质出血在其退化期间达到高峰，其中一些破裂进入侧脑室。到28周时，同源原发性脑沟已经出现，在两个半球出现的胎龄略有不同。在妊娠晚期，继发性孕产是半球独有的。尽管强调神经易感性，但白质病变的患病率超过灰质，在白质内，弥漫性白质星形细胞病的患病率超过局灶性坏死。灰质低血压病变最常发生在上脑干和丘脑，其次是引起硬化性小脑回的凸性交界区病变。灰质体积正常的白质发育不全有时伴有髓鞘发育不足。(c) 2005年爱思唯尔爱尔兰有限公司出版
In this review we focus primarily on the events taking place in the second half of gestation. At second trimester end, human brain weight gain accelerates rapidly. Germinal matrix attains maximal absolute volume, only to ablate 50% over two gestational weeks. At 10 weeks of gestation interhemispheric, choroidal, and transverse fissures exist. Germinal, matrix hemorrhages peak during its devolution and some of these rupture into the lateral ventricle. By 28 weeks homologous primary sulci are present, having appeared in both hemispheres at slightly different gestational ages. Secondary sulcation, during the third trimester, is hemispherically unique. Despite emphasis on neuronal vulnerability, prevalence of lesions in white matter exceeds that of gray matter and, within white matter, diffuse white matter astrocytosis prevalence exceeds that of focal necroses. Gray matter hypotensive lesions most commonly occur in the upper brainstem and thalami followed by convexity borderzone lesions causing sclerotic microgyria. White matter hypoplasia with normal gray matter volume is sometimes associated with hypomyelination. (c) 2005 Published by Elsevier Ireland Ltd.