Ion channels: Manipulating the munchies in mice.

Ion channels: Manipulating the munchies in mice.
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离子通道:操纵小鼠的零食。

DOI:
10.1038/nchembio.697
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发表时间:
2011
影响因子:
14.8
通讯作者:
Akabas,MylesH
Akabas,MylesH
中科院分区:
生物学1区
文献类型:
--
作者:
Akabas,MylesH

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Crystal structure and drug pharmacophore structure-activity data guided a combined mutagenesis and chemical screen to develop ligand-gated ion channels activated by unique chemical agonists. Through genetic engineering, these channels can be used to manipulate neuronal excitability and dissect the neuronal circuitry responsible for complex behaviors.
DOI: 10.1016/j.jmb.2004.12.031
发表时间: 2005-03-04
影响因子: 5.6
作者:
Unwin, N
通讯作者: Unwin, N