Susceptibility-weighted imaging at 7 T: Improved diagnosis of cerebral cavernous malformations and associated developmental venous anomalies.
Susceptibility-weighted imaging at 7 T: Improved diagnosis of cerebral cavernous malformations and associated developmental venous anomalies.
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DOI：
10.1016/j.nicl.2012.09.005
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发表时间：
2012
影响因子：
4.2
通讯作者：
Trattnig, Siegfried
中科院分区：
文献类型：
--
作者：
Frischer, Josa M.;Goed, Sabine;Gruber, Andreas;Saringer, Walter;Grabner, Guenther;Gatterbauer, Brigitte;Kitz, Klaus;Holzer, Sabrina;Kronnerwetter, Claudia;Hainfellner, Johannes A.;Knosp, Engelbert;Trattnig, Siegfried
在脑海绵状血管畸形（CCM）的诊断中，磁共振成像被确立为金标准。常规MRI技术在诊断CCM和相关静脉畸形（DVA）方面存在缺陷。本研究的目的是评价磁敏感加权成像SWI在7 T和3 T条件下检测CCM和相关DVA的效果。24例患者（14例女性，10例男性;中位年龄：38.3岁（21.1岁-69.1岁））入组研究。入组研究的患者在同一天接受了3 T和7 T MRI。在两种场强下应用以下序列：T1加权3D GRE序列（MP-GRE）和SWI序列。在获得研究MRI后，11名患者接受了手术，13名患者接受了保守随访或放射外科治疗。患者最初表现为出血（n = 4，16.7%）、癫痫发作（n = 2，8.3%）或其他神经系统疾病（n = 18，75.0%）。对于手术切除的病变，组织病理学结果证实了CCM的诊断。与3 TSWI相比，7 TSWI序列诊断的CCM数量显著更高（p < 0.05）。与3 T MRI上的初始病变相比，7 T MRI上额外诊断的病变明显更小（p < 0.001）。此外，与3 T MRI相比，7 T MRI诊断出更多相关的DVA。超高场MRI的SWI序列可改善CCM和相关DVA的诊断，因此可增加重要的术前信息。
In the diagnosis of cerebral cavernous malformations (CCMs) magnetic resonance imaging is established as the gold standard. Conventional MRI techniques have their drawbacks in the diagnosis of CCMs and associated venous malformations (DVAs). The aim of our study was to evaluate susceptibility weighted imaging SWI for the detection of CCM and associated DVAs at 7 T in comparison with 3 T. 24 patients (14 female, 10 male; median age: 38.3 y (21.1 y–69.1 y) were included in the study. Patients enrolled in the study received a 3 T and a 7 T MRI on the same day. The following sequences were applied on both field strengths: a T1 weighted 3D GRE sequence (MP-RAGE) and a SWI sequence. After obtaining the study MRIs, eleven patients underwent surgery and 13 patients were followed conservatively or were treated radio-surgically. Patients initially presented with haemorrhage (n = 4, 16.7%), seizures (n = 2, 8.3%) or other neurology (n = 18, 75.0%). For surgical resected lesions histopathological findings verified the diagnosis of CCMs. A significantly higher number of CCMs was diagnosed at 7 T SWI sequences compared with 3 T SWI (p < 0.05). Additionally diagnosed lesions on 7 T MRI were significantly smaller compared to the initial lesions on 3 T MRIs (p < 0.001). Further, more associated DVAs were diagnosed at 7 T MRI compared to 3 T MRI. SWI sequences at ultra-high-field MRI improve the diagnosis of CCMs and associated DVAs and therefore add important pre-operative information.
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影响因子：
5.6
作者：
Baumann, Christian R.;Acciarri, Nicola;Siegel, Adrian M.
通讯作者：
Siegel, Adrian M.
影响因子：
4.1
作者：
ROBINSON, JR;AWAD, IA;LITTLE, JR
通讯作者：
LITTLE, JR
影响因子：
8.3
作者：
Pantano, P;Caramia, F;von Kummer, R
通讯作者：
von Kummer, R
DOI：
10.3174/ajnr.a1461
发表时间：
2009-02
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Mittal S;Wu Z;Neelavalli J;Haacke EM
通讯作者：
Haacke EM
影响因子：
4.1
作者：
Kamezawa, T;Hamada, JI;Kuratsu, JI
通讯作者：
Kuratsu, JI