Adult and prenatal exposures to tobacco smoke as risk indicators of fertility among 430 Danish couples.
Adult and prenatal exposures to tobacco smoke as risk indicators of fertility among 430 Danish couples.
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430 名丹麦夫妇的成人和产前接触烟草烟雾作为生育风险指标。
DOI：
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发表时间：
1998
影响因子：
5
通讯作者：
Jørn Olsen
中科院分区：
文献类型：
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作者：
T. Jensen;T. Henriksen;N. H. Hjollund;T. Scheike;H. Kolstad;A. Giwercman;E. Ernst;J. Bonde;N. Skakkebæk;Jørn Olsen
1992-1995年间，在全国范围内向52,255名20-35岁、与伴侣同居、没有子女的工会成员邮寄了一封信，招募了430对丹麦夫妇。这些夫妇在停止节育时加入了这项研究，并对他们进行了六个月经周期的跟踪，或者直到临床确认的怀孕。在登记时和整个随访期间的每个月，两位伴侣都完成了一份问卷，询问他们吸烟、饮酒和咖啡因饮料的摄入量。用Logistic回归模型评估当前吸烟和宫内吸烟暴露的影响，每个周期的妊娠结局在Cox离散模型中计算受孕优势比。在调整了女性体重指数、饮酒量、女性生殖器官疾病、精液质量和月经周期等因素后，宫内暴露的吸烟者与非吸烟者的受孕优势比为0.53(95%可信区间为0.31~0.91)。宫内暴露的不吸烟妇女的受孕优势比为0.70(95%CI为0.48~1.03)，未暴露于宫内的女性吸烟者的受孕优势比为0.67(95%CI为0.42~1.06)。宫内暴露也与男性受孕优势比降低有关(0.68，95%可信区间0.48-0.97)，而目前吸烟并不显著降低受孕能力。在尝试怀孕之前和怀孕期间，鼓励戒烟似乎是明智的。
During 1992-1995, 430 Danish couples were recruited after a nationwide mailing of a letter to 52,255 trade union members who were 20-35 years old, lived with a partner, and had no children. The couples were enrolled into the study when they discontinued birth control, and they were followed for six menstrual cycles or until a clinically recognized pregnancy. At enrollment and each month throughout the follow-up, both partners completed a questionnaire that asked them about their smoking, alcohol consumption, and intake of caffeinated beverages. The effect of current smoking and smoking exposure in utero was evaluated by using a logistic regression model with pregnancy outcome of each cycle in a Cox discrete model calculating the fecundability odds ratio. After adjustment for female body mass index and alcohol intake, diseases in female reproductive organs, semen quality, and duration of menstrual cycle, the fecundability odds ratio for smoking women exposed in utero was 0.53 (95% confidence interval (CI) 0.31-0.91) compared with unexposed nonsmokers. Fecundability odds ratio for nonsmoking women exposed in utero was 0.70 (95% CI 0.48-1.03) and that for female smokers not exposed in utero was 0.67 (95% CI 0.42-1.06). Exposure in utero was also associated with a decreased fecundability odds ratio in males (0.68, 95% CI 0.48-0.97), whereas present smoking did not reduce fecundability significantly. It seems advisable to encourage smoking cessation prior to the attempt to conceive as well as during pregnancy.
影响因子：
5
作者：
MICKEY, RM;GREENLAND, S
通讯作者：
GREENLAND, S