Functional Imaging Patterns in Alzheimer's Disease Relationships to Neurobiology a
Functional Imaging Patterns in Alzheimer's Disease Relationships to Neurobiology a
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阿尔茨海默病的功能成像模式与神经生物学的关系
DOI：
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发表时间：
1996
影响因子：
5.2
通讯作者：
W. Jagust
中科院分区：
文献类型：
--
作者：
W. Jagust
正电子发射断层扫描(PET)和单光子发射计算机断层扫描(SPECT)等脑功能成像技术已广泛应用于痴呆的研究。虽然颞叶和顶叶低代谢和低灌流的模式通常被认为是诊断有用的，以确定痴呆是由阿尔茨海默病(AD)所致，但这种模式在临床重要情况下的确切敏感性和特异性尚不清楚。然而，这些影像表现在描述疾病好发的区域模式方面有相当大的兴趣。有证据支持这样的观点，即阿尔茨海默病最早的功能损害部位是在颞叶。然而，令人惊讶的是，与一组健康的老年受试者相比，在一组轻度痴呆的AD患者中很难检测到近侧颞叶代谢低下。这些结果表明，简单地使用内侧颞叶代谢率作为AD的诊断可能并不是有效的，通过调查健康的老年人可以最有效地研究AD早期阶段的评估。
Brain imaging with functional techniques, such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) have been widely applied to the study of dementia. While the pattern of temporal and parietal hypometabolism and hypoperfusion have often been suggested to be of diagnostic utility in ascertaining that a dementia is due to Alzheimer's disease (AD), the exact sensitivity and specificity of this pattern in clinically important situations is unclear. These imaging findings have been of considerable interest, however, in describing the regional patterns of predilection in the disease. Evidence supports the contention that the earliest sites of functional impairment in AD are in the temporal lobes. Surprisingly, however, mesial temporal lobe hypometabolism was difficult to detect in a group of mildly demented AD patients in comparison to a group of healthy older subjects. These results suggest that simple use of mesial temporal lobe metabolic rates as a diagnostic for AD may not be fruitful, and that evaluation of the earliest stages of AD can be most productively studied by investigating healthy older individuals.
阿尔茨海默氏病局部脑血流量的认知相关性。
影响因子：
--
作者：
Eberling,JL;Reed,BR;Baker,MG;Jagust,WJ
通讯作者：
Jagust,WJ
阿尔茨海默病和额叶痴呆的临床生理相关性。
DOI：
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发表时间：
1989
期刊：
American journal of physiologic imaging
影响因子：
--
作者：
Jagust,WJ;Reed,BR;Seab,JP;Kramer,JH;Budinger,TF
通讯作者：
Budinger,TF