A linkage map of distal mouse chromosome 4 in the vicinity of Ssm1, a strain-specific modifier of methylation.
A linkage map of distal mouse chromosome 4 in the vicinity of Ssm1, a strain-specific modifier of methylation.
复制标题
小鼠 4 号染色体远端 Ssm1 附近的连锁图，Ssm1 是一种菌株特异性甲基化修饰剂。
DOI：
10.1007/s003350010124
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Storb,U
中科院分区：
文献类型：
--
作者：
Engler,P;Storb,U
The article reports on a linkage map of distal mouse chromosome 4 in the vicinity of Ssm1, a strain specific modifier of methylation. Inactive chromosomal regions are often characterized by the pres-ence of 5-methyl cytosine in CpG dinucleotides and by hypoacetylated histones. A direct biochemical link between CpG methylation and chromatin structure has now been established. The linkage map is based on analysis of a 500 mouse backcross panel. On the basis of the original low resolution mapping of Ssml with recombinant inbred mice and the available maps of SSR loci, it was considered likely that Ssml would be in the interval between D4Mit54 and D4Mit42.
