Copper Sulfide Nanoparticles with Phospholipid-PEG Coating for In Vivo Near-Infrared Photothermal Cancer Therapy
Copper Sulfide Nanoparticles with Phospholipid-PEG Coating for In Vivo Near-Infrared Photothermal Cancer Therapy
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DOI：
10.1002/asia.201403133
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发表时间：
2015-02-01
影响因子：
4.1
通讯作者：
Chen, Xiaolan
中科院分区：
文献类型：
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作者：
Huang, Yizhuan;Lai, Yulian;Chen, Xiaolan
在这项工作中，小尺寸的疏水性硫化铜纳米粒子（CuS NPs，类似于3.8 nm的直径）已成功地制备从氯化铜与二乙基二硫代氨基甲酸钠（SDEDTC）内的加热油胺溶液的反应。这些CuS NP在700-1100 nm近红外（NIR）区域显示出强吸收。通过在CuS NPs表面涂覆DSPE-PEG 2000，合成的CuS@DSPE-PEG NPs表现出良好的水溶性、显著的稳定性和生物相容性，以及在暴露于808 nm激光时优异的光热转换效果。小鼠静脉给药后，发现CuS@DSPE-PEG纳米粒被动靶向肿瘤部位，在激光照射下可以有效消融肿瘤组织。此外，通过组织学和血液化学分析，CuS@DSPE-PEG NP未显示出显著的毒性，并且可以通过代谢有效地排出。我们的研究结果表明，CuS@DSPE-PEG NPs可以作为一种理想的光热剂用于癌症光热治疗。
In this work, small sizes of hydrophobic copper sulfide nanoparticles (CuS NPs, similar to 3.8 nm in diameter) have been successfully prepared from the reaction of copper chloride with sodium diethyldithiocarbamate (SDEDTC) inside a heated oleylamine solution. These CuS NPs displayed strong absorption in the 700-1100 nm near-infrared (NIR) region. By coating CuS NPs with DSPE-PEG2000 on the surface, the as-synthesized CuS@DSPE-PEG NPs exhibited good water solubility, significant stability and biocompatibility, as well as excellent photothermal conversion effects upon exposure to an 808 nm laser. After intravenous administration to mice, the CuS@DSPE-PEG NPs were found to passively target to the tumor site, and tumor tissues could be ablated efficiency under laser irradiation. In addition, CuS@DSPE-PEG NPs do not show significant toxicity by histological and blood chemistry analysis, and can be effectively excreted via metabolism. Our results indicated that CuS@DSPE-PEG NPs can act as an ideal photothermal agent for cancer photothermal therapy.