FAMILIAL AND ACQUIRED PAROXYSMAL DYSKINESIAS - PROPOSED CLASSIFICATION WITH DELINEATION OF CLINICAL FEATURES
FAMILIAL AND ACQUIRED PAROXYSMAL DYSKINESIAS - PROPOSED CLASSIFICATION WITH DELINEATION OF CLINICAL FEATURES
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DOI：
10.1001/archneur.1978.00500360051010
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发表时间：
1978-01-01
影响因子：
--
通讯作者：
CHUN, RWM
中科院分区：
文献类型：
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作者：
GOODENOUGH, DJ;FARIELLO, RG;CHUN, RWM
在临床基础上，阵发性运动障碍可分为2个不同的类别，家族性和获得性。前者开始于儿童期，运动障碍可能是由突然运动引起的（运动诱发或非运动诱发形式）。在家族性运动诱发型中，运动是短暂的，通常每天发生，并且对抗惊厥药容易应答。这种形式具有常染色体显性或隐性遗传方式。在家族性非运动诱发型中，运动持续时间较长，发生频率较低，对抗惊厥药很少反应。这种形式具有明显的常染色体显性遗传方式。病因不明。获得性阵发性运动障碍发作较晚，是潜在神经或代谢疾病的表现。一些获得性阵发性运动障碍的病例是不寻常形式的癫痫的表现。在这些情况下，鉴别诊断可能是非常困难的，必须根据发作期间的脑电图结果。
On a clinical basis the paroxysmal dyskinesias can be classified into 2 distinct categories, familial and acquired. The former begins in childhood and the dyskinesia may or may not be induced by sudden movements (kinesigenic or nonkinesigenic forms). In the familial kinesigenic form, the movements are brief, usually occur daily and respond readily to anticonvulsants. This form has an autosomal dominant or recessive mode of inheritance. In the familial nonkinesigenic form, the movements are of longer duration, occur less frequently and rarely respond to anticonvulsants. This form has a clear autosomal dominant mode of inheritance. The etiology is obscure. The acquired form of paroxysmal dyskinesia has a later onset and is an expression of an underlying neurological or metabolic disease. Some cases of acquired paroxysmal dyskinesia are manifestations of unusual forms of epilepsy. In these cases the differential diagnosis may be extremely difficult and must be based on EEG findings during an ictal episode.