Mitochondria and ageing.
Mitochondria and ageing.
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DOI：
10.1097/00075197-200011000-00009
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发表时间：
2000-11-01
影响因子：
3.1
通讯作者：
Turnbull, D M
中科院分区：
文献类型：
--
作者：
Cottrell, D A;Turnbull, D M
线粒体一直被认为是衰老的罪魁祸首。我们在这里审查的时间顺序的变化，在细胞中积累的证据，并讨论这些变化如何可能导致细胞功能障碍和死亡。我们的结论是，虽然在线粒体中的氧化应激水平，DNA突变和生化缺陷的老化变化的证据是令人信服的，有很少的实验证据，这些变化直接与细胞病理老化。解决这一问题的有希望的途径包括调查已建立的线粒体DNA疾病和线粒体缺陷的动物模型的发展。
Mitochondria have long been proposed as a perpetrator of aging. We review here the accumulating evidence for chronological alterations in the mitochondrion and discuss how these changes may cause cellular dysfunction and death. We conclude that although the evidence for aging changes in the level of oxidative stress, DNA mutations and biochemical deficiencies in mitochondria are convincing, there is little experimental evidence to link these changes directly with the cellular pathology of aging. Promising avenues for addressing this problem include the investigation of established mitochondrial DNA disorders and the development of animal models with mitochondrial defects.