Neural mechanisms of movement planning: motor cortex and beyond
Neural mechanisms of movement planning: motor cortex and beyond
复制标题
DOI：
10.1016/j.conb.2017.10.023
复制
发表时间：
2018-04-01
影响因子：
5.7
通讯作者：
Lie, Nuo
中科院分区：
文献类型：
--
作者：
Svoboda, Karel;Lie, Nuo
运动皮层和相连的大脑区域中的神经元在运动发生之前很久就已经对特定的运动产生了预期。这种神经活动反映了大脑计划和执行意志运动的内部过程。运动规划的研究提供了一个机会，了解神经回路的结构和动力学如何支持持久的内部状态，以及这些状态如何影响行为。大规模神经记录的最新进展开始破译运动规划和运动过程中神经元群体的动力学关系。啮齿动物的新行为任务，加上量化的扰动，将神经回路特定节点的动态与行为联系起来。这些研究揭示了一个分布在多个大脑区域的神经网络，这些区域共同支持运动规划。我们回顾了最近的进展，并强调需要进一步工作的领域，以实现更深入的了解运动规划和相关的认知过程的机制。
Neurons in motor cortex and connected brain regions fire in anticipation of specific movements, long before movement occurs. This neural activity reflects internal processes by which the brain plans and executes volitional movements. The study of motor planning offers an opportunity to understand how the structure and dynamics of neural circuits support persistent internal states and how these states influence behavior. Recent advances in large-scale neural recordings are beginning to decipher the relationship of the dynamics of populations of neurons during motor planning and movements. New behavioral tasks in rodents, together with quantified perturbations, link dynamics in specific nodes of neural circuits to behavior. These studies reveal a neural network distributed across multiple brain regions that collectively supports motor planning. We review recent advances and highlight areas where further work is needed to achieve a deeper understanding of the mechanisms underlying motor planning and related cognitive processes.