High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing
High-speed polarization sensitive optical frequency domain imaging with frequency multiplexing
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DOI：
10.1364/oe.16.001096
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发表时间：
2008-01-21
期刊：
影响因子：
3.8
通讯作者：
Bouma, E.
中科院分区：
文献类型：
--
作者：
Oh, W. Y.;Yun, S. H.;Bouma, E.
偏振敏感光学相干断层扫描（PS-OCT）提供生物样品中的双折射的横截面图像，其在许多应用中与基于标准反射率的图像互补。最近的离体研究表明，双折射映射能够表征血管组织中胶原蛋白和平滑肌的浓度和分布。能够在体内持续应用这些测量的仪器可能会为冠状动脉粥样硬化和急性心肌梗死提供新的见解。我们开发了一种偏振敏感光频域成像（PS-OFDI）系统，通过光纤导管实现高速血管内双折射成像。该系统的新颖设计利用频率复用来同时测量两个入射偏振态的反射率，克服了关于导管光纤双折射的时间变化和样品双折射的空间变化的担忧。我们展示了通过具有62 kHz的A线速率和6.2 mm的测距深度的柔性光纤导管对离体人类冠状动脉的圆形横截面双折射成像。（c）2008年美国光学学会。
Polarization sensitive optical coherence tomography (PS-OCT) provides a cross-sectional image of birefringence in biological samples that is complementary in many applications to the standard reflectance-based image. Recent ex vivo studies have demonstrated that birefringence mapping enables the characterization of collagen and smooth muscle concentration and distribution in vascular tissues. Instruments capable of applying these measurements percutaneously in vivo may provide new insights into coronary atherosclerosis and acute myocardial infarction. We have developed a polarization sensitive optical frequency domain imaging (PS-OFDI) system that enables high-speed intravascular birefringence imaging through a fiber-optic catheter. The novel design of this system utilizes frequency multiplexing to simultaneously measure reflectance of two incident polarization states, overcoming concerns regarding temporal variations of the catheter fiber birefringence and spatial variations in the birefringence of the sample. We demonstrate circular cross-sectional birefringence imaging of a human coronary artery ex vivo through a flexible fiber-optic catheter with an A-line rate of 62 kHz and a ranging depth of 6.2 mm. (c) 2008 Optical Society of America.