Smart bandage with wireless connectivity for uric acid biosensing as an indicator of wound status
Smart bandage with wireless connectivity for uric acid biosensing as an indicator of wound status
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DOI：
10.1016/j.elecom.2015.03.018
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发表时间：
2015-07-01
影响因子：
5.4
通讯作者：
Wang, Joseph
中科院分区：
文献类型：
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作者：
Kassal, Petar;Kim, Jayoung;Wang, Joseph
先进的伤口护理技术需要不断发展，以应对慢性伤口对国家医疗保健预算日益增加的负担以及慢性伤口对患者生活质量的破坏性影响。我们在这里描述了一种新型的智能绷带，用于测定尿酸（UA）状态，尿酸是一种关键的伤口生物标志物，通过将电流型生物传感器直接丝网印刷在伤口敷料上形成。固定化尿酸酶与印刷的催化普鲁士蓝传感器配对，有利于在低工作电位下计时电流检测尿酸。智能绷带生物传感器与定制设计的可穿戴恒电位仪连接，该恒电位仪通过射频识别（RFID）或近场通信（NFC）向计算机、平板电脑或智能手机提供UA状态的按需无线数据传输。智能绷带的灵敏度，选择性，操作稳定性和机械鲁棒性的分析性能进行了描述。这些绷带的应用将提供对伤口状态的洞察，并可能减少更换敷料的频率，从而节省医疗成本并减少患者的压力和疼痛。(C)2015 Elsevier B.V.版权所有。
Advanced wound care technologies need to evolve in response to the growing burden of chronic wounds on national healthcare budgets and the debilitating impact chronic wounds have on patient quality of life. We describe here a new type of smart bandage for determination of uric acid (UA) status, a key wound biomarker, formed by screen printing an amperometric biosensor directly on a wound dressing. Immobilized uricase, paired with a printed catalytic Prussian blue transducer, facilitates chronoamperometric detection of uric add at a low working potential. The smart bandage biosensor interfaces with a custom designed wearable potentiostat that provides on-demand wireless data transfer of UA status to a computer, tablet, or Smartphone by radio frequency identification (RFID) or near-field communication (NFC). The analytical performance of the smart bandage sensitivity, selectivity, operational stability, and mechanical robustness is described. Application of these bandages will provide insight into wound status and may reduce the frequency at which dressings are changed, allowing for healthcare cost savings and a reduction in patient stress and pain. (C) 2015 Elsevier B.V. All rights reserved.