Double-mode relaxation of highly deformed anisotropic vesicles
Double-mode relaxation of highly deformed anisotropic vesicles
复制标题
高度变形各向异性囊泡的双模式弛豫
DOI：
10.1103/physreve.102.010605
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发表时间：
2020
影响因子：
2.4
通讯作者：
Schroeder, Charles M.
中科院分区：
文献类型：
--
作者：
Kumar, Dinesh;Richter, Channing M.;Schroeder, Charles M.
脂质囊泡是已知的，经历复杂的构象转变，但它仍然具有挑战性的系统性特征的非平衡膜动力学流动。在这里，我们报告的直接观察各向异性囊泡松弛高度变形的形状使用斯托克斯陷阱。囊泡形状松弛描述由两个不同的特征的时间尺度由弯曲模量和膜张力。有趣的是，发现快速的双模时间尺度取决于囊泡放气或体积减小。实验结果很好地描述了变形膜的粘弹性模型。总体而言，这些结果表明，囊泡松弛是由膜弹性模量，表面张力和囊泡放气之间的相互作用。
Lipid vesicles are known to undergo complex conformational transitions, but it remains challenging to systematically characterize nonequilibrium membrane dynamics in flow. Here, we report the direct observation of anisotropic vesicle relaxation from highly deformed shapes using a Stokes trap. Vesicle shape relaxation is described by two distinct characteristic timescales governed by the bending modulus and membrane tension. Interestingly, the fast double-mode timescale is found to depend on vesicle deflation or reduced volume. Experimental results are well described by a viscoelastic model of a deformed membrane. Overall, these results show that vesicle relaxation is governed by an interplay between membrane elastic moduli, surface tension, and vesicle deflation.