Lighting up spin systems: enhancing characteristic 1H signal patterns of fluorinated molecules.
Lighting up spin systems: enhancing characteristic 1H signal patterns of fluorinated molecules.
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点亮自旋系统：增强氟化分子的特征 1H 信号模式。
DOI：
10.1039/d3cc03557c
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Smith MJ
中科院分区：
文献类型：
--
作者：
Smith MJ
氟在药物化学中越来越普遍，在药物分子和分子探针中都是如此。氟的存在使人们可以通过核磁共振光谱学方便地监测复杂环境中的此类分子。然而，灵敏度是核磁共振的一个持久的限制，特别是当分子存在于低浓度时。在这里，通过与1H核共享19F光化学诱导的动态核极化来缓解1H核磁共振的敏感性问题。与直接1H增强不同的是，这种方法增强了1H信号，而不会显著扭曲多重态强度，并有可能将合适的分子用作低浓度探针。
Fluorine is becoming increasingly prevalent in medicinal chemistry, both in drug molecules and in molecular probes. The presence of fluorine allows convenient monitoring of such molecules in complex environments by NMR spectroscopy. However, sensitivity is a persistent limitation of NMR, especially when molecules are present at low concentrations. Here, sensitivity issues with 1H NMR are mitigated by sharing 19F photochemically-induced dynamic nuclear polarisation with 1H nuclei. Unlike direct 1H enhancement, this method enhances 1H signals without significantly distorting multiplet intensities, and has the potential to enable the use of suitable molecules as low-concentration probes.