Visual impairment and cancer: a population-based cohort study in Finland
Visual impairment and cancer: a population-based cohort study in Finland
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DOI：
10.1023/a:1008897317401
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发表时间：
1999-02-01
影响因子：
2.3
通讯作者：
Rudanko, SL
中科院分区：
文献类型：
--
作者：
Pukkala, E;Verkasalo, PK;Rudanko, SL
目的：描述芬兰视力障碍患者的癌症风险模式。方法：从1983- 1995年，通过芬兰癌症登记处对17557名从芬兰视力障碍登记处确定的患者进行癌症随访。视力障碍的程度从视力低于0.3的中度低视力到完全失明，没有光的感觉。标准化发病率比（SIR）和95%置信区间（CI）按原发部位计算；预期的发病率是根据全国癌症发病率得出的。结果：在全盲男性中，总体癌症的SIR为2.2 (CI = 1.3-3.5)，而在整个队列中，发病率仅增加了15%（观察到1255例癌症，预期1093例）。在肝癌（SIR = 1.8, CI = 1.2-2.5）和肺癌（SIR = 1.5, CI = 1.3-1.7）中，男女均观察到过量；女性胃癌（SIR = 1.5, CI = 1.2-1.9）和结直肠癌（SIR = 1.3, CI = 1.1-1.6）；男性肾癌（SIR = 1.8, CI = 1.1-2.6）和眼癌（SIR = 5.8, CI = 1.9-13）。肺癌的过量完全可归因于年龄相关性黄斑变性（这在吸烟者中最常见）。结论：在大多数癌症类型中，视障人群的癌症发病率都有增加的趋势。应注意观察到的风险增加背后的生活方式因素，如不平衡的饮食。
Objectives: To describe the cancer risk pattern of Finnish persons with visual impairment.Methods: A cohort of 17,557 persons identified from the Finnish Register of Visual Impairment was followed-up for cancer through the Finnish Cancer Registry from 1983-95. The degree of visual impairment ranged from moderate low Vision with visual acuity less than 0.3, to total blindness with no perception of light. The standardized incidence ratios (SIR) and 95% confidence intervals (CI) were calculated by primary site; the expected rates were based on national cancer incidence rates.Results: The SIR for overall cancer among totally blind men was 2.2 (CI = 1.3-3.5) while in the entire cohort the incidence was increased by only 15% (1,255 cancers observed cf 1,093 expected). Excesses were observed in both genders in cancers of the liver (SIR = 1.8, CI = 1.2-2.5) and lung (SIR = 1.5, CI = 1.3-1.7); in females in cancers of the stomach (SIR = 1.5, CI = 1.2-1.9) and the colorectum (SIR = 1.3, CI = 1.1-1.6); and in males in cancers of the kidney (SIR = 1.8, CI = 1.1-2.6) and the eye (5.8, CI = 1.9-13). The excess in lung cancer was entirely attributable to age-related macular degeneration (which is most common among smokers).Conclusions: Cancer incidence among the visually impaired tended to be increased for most cancer types. Attention should be paid to lifestyle factors underlying the observed risk increases, such as unbalanced diet.