Prevalence and determinants of antibiotic exposure in infants: A population-derived Australian birth cohort study
Prevalence and determinants of antibiotic exposure in infants: A population-derived Australian birth cohort study
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DOI：
10.1111/jpc.13616
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发表时间：
2017-10-01
影响因子：
1.7
通讯作者：
Burgner, David
中科院分区：
文献类型：
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作者：
Anderson, Hayley;Vuillermin, Peter;Burgner, David
目的：本研究的目的是描述澳大利亚婴儿出生第一年的抗生素暴露情况，重点介绍抗生素的种类、适应症、与暴露相关的危险因素以及与国际同行的比较。方法：巴元婴儿研究是一项出生队列研究(n=1074)，采用澳大利亚维多利亚州一个大型区域中心的未经选择的产前抽样框架。分别于1、3、6、9、12个月通过家长问卷、全科医生和住院病历收集感染和用药的纵向资料。确定了问卷未完成的预测因素。本研究对660名具有完整系列资料的婴儿进行了全面检查。结果：平均每人年抗菌药物处方使用率为0.92张(95%可信区间，0.83~1.02)，老年组最高
Aim: The aim of this study was to describe antibiotic exposure in Australian infants during the first year of life, focusing on antibiotic class, indication, risk factors associated with exposure and comparison with international counterparts.Methods: The Barwon Infant Study is a birth cohort study (n=1074) with an unselected antenatal sampling frame from a large regional centre in Victoria, Australia. Longitudinal data on infection and medication were collected at 1, 3, 6, 9 and 12 months by parental questionnaire and from general practitioner and hospital records. Predictors of questionnaire non-completion were identified. A total of 660 infants with complete serial data were comprehensively examined. Antibiotic exposure was calculated as (i) antibiotic prescriptions and (ii) antibiotic days-exposed per person-year.Results: Mean antibiotic prescription rate was 0.92 prescriptions (95% confidence interval (CI), 0.83-1.02) per person-year, with the highest rates in those aged