Environmental enrichment and chronic restraint stress in ICR mice: Effects on prepulse inhibition of startle and Y-maze spatial recognition memory
Environmental enrichment and chronic restraint stress in ICR mice: Effects on prepulse inhibition of startle and Y-maze spatial recognition memory
复制标题
ICR 小鼠的环境富集和慢性束缚应激：对惊吓和 Y 迷宫空间识别记忆的前脉冲抑制的影响
DOI：
10.1016/j.bbr.2010.03.033
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发表时间：
2010-09-01
影响因子：
2.7
通讯作者：
Ma, Yuanye
中科院分区：
文献类型：
--
作者：
Chen, Yanmei;Mao, Yu;Ma, Yuanye
在大多数关于丰富环境(EE)的改善或治疗效果的研究中，丰富环境是在应激治疗后或在某些疾病患者中进行的。在本研究中，测试了长期束缚应激(6h/d)对生活在丰富环境和标准环境(SE)中的小鼠的影响。将小鼠随机分为4组：非应激组或应激组，分别置于SE、应激+SE、EE、应激+EE条件下。在应激和/或EE治疗2周或4周以及停药1周或2周后，检测惊厥的预脉冲抑制(PPI)。治疗4周后，进行Y迷宫空间再认记忆测试。结果表明，EE治疗2周后，应激和非应激小鼠的PPI均升高。治疗4周后，EE对PPI无明显影响。4周的慢性束缚应激增加了标准条件下小鼠的PPI，但不增加EE条件下的PPI。应激小鼠在延迟1小时的Y迷宫中表现出缺陷，这可以通过生活在丰富的环境中来防止。我们的结果表明，生活在一个丰富的环境中，可以逆转慢性束缚应激对空间识别记忆的损害。然而，EE并不改变应激对PPI的影响。(C)2010爱思唯尔B.V.保留所有权利。
In most studies regarding the improving or therapeutical effects induced by enriched environment (EE), EE was performed after the stress treatment or in patients with certain diseases. In the current study, the effects of chronic restraint stress (6 h/day) in mice living in an enriched environment or standard environment (SE) were tested. Mice were randomly divided into 4 groups: non-stressed or stressed mice housed in SE or EE conditions (SE, stress + SE, EE, stress + EE). Prepulse inhibition (PPI) of startle was tested after the 2 weeks or 4 weeks stress and/or EE treatment and 1 or 2 weeks withdrawal from the 4 weeks treatment. After the 4 weeks treatment, spatial recognition memory in Y-maze was also tested. The results showed that EE increased PPI in stressed and non-stressed mice after 2 weeks treatment. No effect of EE on PPI was found after the 4 weeks treatment. 4 weeks chronic restraint stress increased PPI in mice housed in standard but not EE conditions. Stressed mice showed deficits on the 1 h delay version of the Y-maze which could be prevented by living in an enriched environment. Our results indicated that living in an enriched environment reversed the impairing effects of chronic restraint stress on spatial recognition memory. However, EE did not change the effects of stress on PPI. (C) 2010 Elsevier B.V. All rights reserved.