Consistent and reproducible slice selection in rodent brain using a novel stereotaxic device for MRI
Consistent and reproducible slice selection in rodent brain using a novel stereotaxic device for MRI
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DOI：
10.1016/j.jneumeth.2004.01.003
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发表时间：
2004-06-15
影响因子：
3
通讯作者：
Faden, AI
中科院分区：
文献类型：
--
作者：
Fricke, ST;Vink, R;Faden, AI
通常，在使用床或平台将动物放置在成像装置的中心之后，然后在获得定位图像之后调整位置，来获得小动物放射图像。这样的过程不允许在重复检查的情况下对相同解剖平面进行可再现的可视化。我们已经开发出一种设备，允许立体定位放置的动物在完全相同的位置进行重复检查。该仪器集成了全方位的生理监测和生命支持系统，包括温度控制、麻醉输送和呼吸监测。使用磁共振成像（MRI），该设备的准确性和可靠性证明在大鼠创伤性脑损伤（TBI）模型。(C)2004 Elsevier B.V.保留所有权利。
Typically small animal radiological images are obtained after placing the animal in the center of the imaging device using beds or platforms, and then adjusting the position after obtaining a scout image. Such a process does not permit the reproducible visualization of the same anatomical plane with repeated examinations. We have developed a device that allows stereotaxic placement of an animal in precisely the same position for repeated examinations. The instrument incorporates a full range of physiological monitoring and life support systems including temperature control, anesthesia delivery and respiratory monitoring. Using magnetic resonance imaging (MRI), the accuracy and reliability of this device is demonstrated in a rat traumatic brain injury (TBI) model. (C) 2004 Elsevier B.V. All rights reserved.