PHTHALIC ANHYDRIDE-INDUCED OCCUPATIONAL ASTHMA
PHTHALIC ANHYDRIDE-INDUCED OCCUPATIONAL ASTHMA
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DOI：
10.1159/000233946
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发表时间：
1986-01-01
期刊：
影响因子：
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通讯作者：
SKERFVING, S
中科院分区：
文献类型：
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作者：
WERNFORS, M;NIELSEN, J;SKERFVING, S
在4家醇酸和/或多不饱和聚酯树脂工厂的118名工人中，暴露于邻苯二甲酸酐（PA）粉尘2个月或更长时间，28人（24%）患有与工作有关的鼻炎，13人（11%）患有慢性生产性支气管炎，21人（28%）患有与工作有关的哮喘。哮喘一般以鼻炎为先发，多为晚期。11例哮喘患者中有3例皮肤试验pa阳性。在2名受试者中，通过prausnitz - k<s:1> stner试验证实存在抗体。25名未患哮喘的重度暴露者中有4人出现非特异性支气管高反应性。结果显示，在鼻炎和哮喘方面，没有任何显著的“健康工人选择”。慢性生产性支气管炎很常见，而且在以前的工人中比在现在的员工中更普遍，这表明工厂中有一些无反应的受试者。两个工厂在不同直接处理PA的作业中，呼吸区PA的时间加权平均水平在3 ~ 13 mg/m3之间，其他作业的呼吸区PA低于0.3 mg/m3。2例受试者分别短期暴露于0.5和6mg PA/m3，支气管刺激呈阳性。
Out of 118 workers exposed to phthalic anhydride (PA) dust for 2 months or more in four plants producing alkyd and/or polyunsaturated polyester resins, 28 (24%) suffered from work-related rhinitis, 13 (11 %) from chronic productive bronchitis, and 21 (28%) from work-associated asthma. Asthma was generally preceded by rhinitis and was mostly of late type. 3 out of 11 asthmatics had a PA-positive skin test. In 2 subjects the presence of antibodies was demonstrated by the Prausnitz-Küstner test. 4 out of 25 heavily exposed subjects without asthma had a nonspecific bronchial hyperreactivity. The results did not indicate any significant ‘healthy worker selection’ as regarding rhinits and asthma. Chronic productive bronchitis was common and was more prevalent among former workers than among present employees, indicating a selection of nonreacting subjects in the plant. The time-weighted average breathing zone PA levels in two plants were between 3 and 13 mg/m3during different direct PA handling operations and less than 0.3 mg/m3at other kinds of work. In 2 subjects, positive bronchial provocation was obtained by short-term exposure to 0.5 and 6 mg PA/m3, respectively.