Dual-tasking and gait in people with mild cognitive impairment. The effect of working memory.
Dual-tasking and gait in people with mild cognitive impairment. The effect of working memory.
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DOI：
10.1186/1471-2318-9-41
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发表时间：
2009-09-01
期刊：
影响因子：
4.1
通讯作者：
Chertkow H
中科院分区：
文献类型：
--
作者：
Montero-Odasso M;Bergman H;Phillips NA;Wong CH;Sourial N;Chertkow H
老年人的认知能力和活动能力密切相关，并随着年龄的增长而下降。评估轻度认知障碍（MCI）患者认知因素与步态表现之间关系的研究很少。在这项研究中，我们的目的是确定特定的认知因素是否对轻度认知障碍患者在双重任务时的步态速度有更明显的影响。55名参与者，平均年龄77.7岁（SD = 5.9），其中45%为女性，患有轻度认知障碍，评估其全球认知、工作记忆、执行功能和注意力。在单任务条件（single GV）和两种双任务条件下测量步态速度（GV）： 1)向后计数（计数GV）， 2)命名动物（言语GV）。采用多变量线性回归分析检验相关性，α水平为0.05。参与者在参与双任务挑战时经历了GV的减少（p < 0.005）。低执行功能和工作记忆表现与单次GV慢（p = 0.038）、计数GV慢（p = 0.017）和言语GV慢（p = 0.031）有关。调整后，工作记忆是唯一的认知因素，仍然与缓慢的GV显著相关。在患有轻度认知障碍的老年人中，较低的工作记忆表现与缓慢的GV有关。双任务条件与步态减慢的关联最强。我们的研究结果表明，大脑皮层对步态的控制与轻度认知障碍患者工作记忆的下降有关。
Cognition and mobility in older adults are closely associated and they decline together with aging. Studies evaluating associations between cognitive factors and gait performance in people with Mild Cognitive Impairment (MCI) are scarce. In this study, our aim was to determine whether specific cognitive factors have a more identifiable effect on gait velocity during dual-tasking in people with MCI. Fifty-five participants, mean age 77.7 (SD = 5.9), 45% women, with MCI were evaluated for global cognition, working memory, executive function, and attention. Gait Velocity (GV) was measured under a single-task condition (single GV) and under two dual-task conditions: 1) while counting backwards (counting GV), 2) while naming animals (verbal GV). Multivariable linear regression analysis was used to examine associations with an alpha-level of 0.05. Participants experienced a reduction in GV while engaging in dual-task challenges (p < 0.005). Low executive function and working memory performances were associated with slow single GV (p = 0.038), slow counting GV (p = 0.017), and slow verbal GV (p = 0.031). After adjustments, working memory was the only cognitive factor which remained significantly associated with a slow GV. In older adults with MCI, low working memory performance was associated with slow GV. Dual-task conditions showed the strongest associations with gait slowing. Our findings suggest that cortical control of gait is associated with decline in working memory in people with MCI.