Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment
Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment
复制标题
碳酸锂处理减弱 d- 和 l-苯丙胺的欣快感和激活作用
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
D. Murphy
中科院分区：
文献类型：
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作者：
D. Kammen;D. Murphy
在一项重复剂量、双盲研究中，9 名抑郁症患者中的 7 名在服用 30 毫克 d-安非他明后，额定欣快感和激活度增加了 4.3 倍。 d-安非他明在产生激活、欣快感和抗抑郁作用方面比相同剂量的 l-安非他明更有效 2 至 2.3 倍。与碳酸锂共同治疗可使 d-安非他明的激活和欣快反应减弱 60% (P<0.001)。对左旋苯丙胺的反应几乎被锂完全消除。这项研究提出了碳酸锂作为治疗安非他明成瘾的辅助剂的可能性。
Seven of nine depressed patients experienced a 4.3-fold increase in rated euphoria and activation following 30 mg d-amphetamine in a replicated dose, double blind study. d-Amphetamine was 2 to 2.3-fold more effective in producing activation, euphoria, and antidepressant effects than the same dose of l-amphetamine.Co-treatment with lithium carbonate produced a 60% (P<0.001) attenuation of the activation and euphoria responses to d-amphetamine. The responses to l-amphetamine were almost completely abolished by lithium. This study raises the possibility of lithium carbonate use as an adjunct in the treatment of amphetamine addiction.