Proton pump inhibitor use does not increase dementia and Alzheimer's disease risk: An updated meta-analysis of published studies involving 642305 patients
Proton pump inhibitor use does not increase dementia and Alzheimer's disease risk: An updated meta-analysis of published studies involving 642305 patients
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DOI：
10.1371/journal.pone.0219213
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发表时间：
2019-07-02
期刊：
影响因子：
3.7
通讯作者：
Feng, Shun Yi
中科院分区：
文献类型：
--
作者：
Song, Ya Qi;Li, Yong;Feng, Shun Yi
最近的研究表明，服用质子泵抑制剂 (PPI) 的人患痴呆症和阿尔茨海默病 (AD) 的风险增加，但这些研究的结果并不一致。这项荟萃分析旨在探讨 PPI 使用者患痴呆症和 AD 的纠正风险。在 PubMed、Web of Science、EMBase 和 ScienceDirect 上进行了相关研究的文献检索。汇总风险比 (HR) 和 95% 置信区间 (CI) 用于评估 PPI 与痴呆和 AD 风险之间的关系。这项荟萃分析纳入了 10 项独立研究，涉及 642305 名参与者。 PPI使用者与痴呆症（HR = 1.04，95% CI 0.92-1.15；I-2 = 95.6%，p < 0.001）和AD（HR = 0.96，95% CI 0.83-1.09；I-2 = 80.7%，p < 0.001）无关。 Begg 和 Egger 的测试没有发现发表偏倚的证据。敏感性分析显示效果估计没有重要差异。目前的证据表明 PPI 的使用不会增加痴呆和 AD 风险。研究之间显着的异质性值得对我们的研究结果进行进一步审查。
Recent studies have indicated an increased risk of dementia and Alzheimer's disease (AD) among people who consume proton pump inhibitors (PPIs), but the results of those studies are inconsistent. This meta-analysis aimed to explore the correction risk of dementia and AD among PPI users. The literature search for relevant studies was conducted in PubMed, Web of Science, EMBase and ScienceDirect. Pooled hazard ratio (HR) and 95% confidence intervals (CIs) were used to assess the relationship between the PPIs and risk of dementia and AD. Ten independent studies that involved 642305 participants were included in this meta-analysis. PPI users were unassociated with dementia (HR = 1.04, 95% CI 0.92-1.15; I-2 = 95.6%, p < 0.001) and AD (HR = 0.96, 95% CI 0.83-1.09; I-2 = 80.7%, p < 0.001). No evidence of publication bias was detected by Begg's and Egger's test. Sensitivity analyses showed no important differences in the estimates of effects. The current evidence indicates that PPI use does not increase dementia and AD risk. The remarkable heterogeneity among the studies warrants a further review of our findings.