Global association between cortical thinning and white matter integrity reduction in schizophrenia.
Global association between cortical thinning and white matter integrity reduction in schizophrenia.
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DOI：
10.1093/schbul/sbt030
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发表时间：
2014-03
影响因子：
6.6
通讯作者：
A. Sasamoto;J. Miyata;M. Kubota;K. Hirao;Ryosaku Kawada;Shinsuke Fujimoto;Yusuke Tanaka;Masaaki Hazama;G. Sugihara;N. Sawamoto;H. Fukuyama;Hidehiko Takahashi;T. Murai
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文献类型：
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作者：
A. Sasamoto;J. Miyata;M. Kubota;K. Hirao;Ryosaku Kawada;Shinsuke Fujimoto;Yusuke Tanaka;Masaaki Hazama;G. Sugihara;N. Sawamoto;H. Fukuyama;Hidehiko Takahashi;T. Murai
以往的神经影像学研究表明，精神分裂症患者的灰质（GM）和白色质（WM）在几个形态学方面都发生了改变。虽然一些研究报道了GM和WM在限制区域的改变之间的关联，但GM和WM病理之间是否存在全局关联尚不清楚。考虑到广泛分布的GM形态变化和WM异常的深刻遗传背景，这将是自然的假设之间的全球关联的病理GM和WM精神分裂症。在这项调查中，我们研究了35名精神分裂症患者和35名健康对照组使用T1加权磁共振成像和扩散张量成像（DTI），并调查了GM厚度和WM分数各向异性（FA）之间的关联作为每个组织的病理代理。为了研究皮质厚度，使用基于表面的分析。计算每个半球的全脑平均皮质厚度，并进行组间比较。对于DTI数据，计算全脑的平均FA，并进行组间比较。随后，平均皮质厚度和平均FA之间的相关性进行了研究。结果显示，精神分裂症患者的平均皮质厚度明显变薄，平均FA明显降低。仅在患者组中，双侧半球的平均皮质厚度和平均FA呈显著正相关。即使在控制了人口统计学和临床变量后，这种相关性仍然显着。因此，我们的研究结果表明，精神分裂症的GM和WM病理在全球范围内交织在一起。
Previous neuroimaging studies have revealed that both gray matter (GM) and white matter (WM) are altered in several morphological aspects in schizophrenia patients. Although several studies reported associations between GM and WM alterations in restricted regions, the existence of a global association between GM and WM pathologies is unknown. Considering the wide distribution of GM morphological changes and the profound genetic background of WM abnormalities, it would be natural to postulate a global association between pathologies of GM and WM in schizophrenia. In this investigation, we studied 35 schizophrenia patients and 35 healthy control subjects using T1-weighted magnetic resonance imaging and diffusion tensor imaging (DTI) and investigated the association between GM thickness and WM fractional anisotropy (FA) as a proxy of pathology in each tissue. To investigate cortical thickness, surface-based analysis was used. The mean cortical thickness for the whole brain was computed for each hemisphere, and group comparisons were performed. For DTI data, mean FA for the whole brain was calculated, and group comparisons were performed. Subsequently, the correlation between mean cortical thickness and mean FA was investigated. Results showed that the mean cortical thickness was significantly thinner, and the mean FA was significantly lower in schizophrenia patients. Only in the patient group the mean cortical thickness and mean FA showed significant positive correlations in both hemispheres. This correlation remained significant even after controlling for demographic and clinical variables. Thus, our results indicate that the GM and WM pathologies of schizophrenia are intertwined at the global level.