EFFECT OF RENIN-ANGIOTENSIN SYSTEM ON SODIUM INTAKE
EFFECT OF RENIN-ANGIOTENSIN SYSTEM ON SODIUM INTAKE
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DOI：
10.1113/jphysiol.1976.sp011269
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发表时间：
1976-01-01
影响因子：
5.5
通讯作者：
CHIARAVIGLIO, E
中科院分区：
文献类型：
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作者：
CHIARAVIGLIO, E
1. 通过 I.P. 测量钠耗尽的大鼠的水和盐水摄入量。透析。双侧肾切除术后 180 分钟（而非 60-90 分钟）禁止钠摄入。单侧肾切除术以及输尿管结扎对钠摄入量没有影响。 2. 腹腔注射肾素 (3u.)重新建立了因肾切除术而消除的钠食欲。 3. 将血管紧张素 I (5 ng) 或 II (5-40 ng) 注射到第三心室，也恢复了 Na 的摄入量，并且这种作用是剂量依赖性的。 4. 血管紧张素转换酶抑制剂 Sq 20,881 (1 mg/kg) 抑制 AI 的作用，但不抑制 AII 恢复钠摄入的作用。 5. 结论是肾脏可能通过肾素-血管紧张素系统在调节钠摄入方面发挥作用。
1. Water and saline intake was measured in rats depleted of Na by I.P. dialysis. Na intake was prevented 180 min but not 60‐90 min after bilateral nephrectomy. Unilateral nephrectomy as well as ureteral ligature had no effect on Na intake. 2. Renin (3u.) injected I.P. re‐established the Na appetite abolished by nephrectomy. 3. Angiotensin I (5 ng) or II (5‐40 ng) injected into the 3rd ventricle, also restored the Na intake and this effect was dose‐dependent. 4. The angiotensin converting‐enzyme inhibitor Sq 20,881 (1 mg/kg) inhibited the effect of AI but not that of AII in restoring Na intake. 5. It is concluded that the kidneys might play a role in the regulation of Na intake through the renin‐angiotensin system.