Atrial pronatriodilatin: a precursor for natriuretic factor and cardiodilatin
Atrial pronatriodilatin: a precursor for natriuretic factor and cardiodilatin
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心房原钠舒张素：利尿钠因子和心脏舒张素的前体
DOI：
10.1016/0014-5793(84)80878-9
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发表时间：
1984
期刊：
影响因子：
3.5
通讯作者：
J. Genest
中科院分区：
文献类型：
--
作者：
C. Lazure;N. Seidah;M. Chrétien;G. Thibault;R. Garcia;M. Cantin;J. Genest
从大鼠心房中分离出许多肽，包括两种含有33和73个氨基酸的肽，并显示出利尿钠活性。在这里，我们描述了含有先前测序的33-和73-氨基酸ANF肽的106-残基肽的纯化和部分氨基酸序列。所确定的序列是新的序列，并且与任何已知的蛋白质或其片段不显著同源。事实上，该序列仅与另一种新的部分序列显示出显著的同源性，所述部分序列是从猪肽的序列分析中获得的，所述猪肽被称为心脏舒张素，也在心房中发现。这种关系被认为是ANF和心脏扩张素是相同前体分子的一部分的证据，该前体分子至少含有126个氨基酸。
Numerous peptides isolated from rat heart atria, including two containing 33 and 73 amino acids, were isolated and shown to exhibit natriuretic activities. Here, we describe the purification and partial amino acid sequence of a 106‐residue peptide containing the previously sequenced 33‐ and 73‐amino‐acid ANF peptides. The determined sequence is a novel one and is not significantly homologous to any known protein or segment thereof. In fact, this sequence shows significant homology only to another novel partial sequence obtained from sequence analysis of a porcine peptide, called cardiodilatin, also found in heart atria. This relationship is taken as evidence that ANF and cardiodilatin are part of the same precursor molecule which would contain at the very least 126 amino acids.
DOI：
10.1073/pnas.81.3.726
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DESCHENES, RJ;LORENZ, LJ;DIXON, JE
通讯作者：
DIXON, JE