Nanoscale porous triazine-based frameworks with cyanate ester linkages for efficient drug delivery
Nanoscale porous triazine-based frameworks with cyanate ester linkages for efficient drug delivery
复制标题
具有氰酸酯键的纳米级多孔三嗪框架可实现高效药物输送
DOI：
10.1039/c6ra01044j
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发表时间：
2016-01-01
期刊：
影响因子：
3.9
通讯作者：
Xiao, Xuxian
中科院分区：
文献类型：
--
作者：
Liu, Junling;Fu, Yu;Xiao, Xuxian
以一种新的三角形单体2，4，6-三（4-氰基苯基）-1，3，5-三嗪为原料，设计并合成了一系列具有氰酸酯键的纳米多孔有机聚三嗪（NOP-14）。在相同的溶剂介质中的四种不同浓度的反应性基团，已被采用，以允许容易地调节孔径。氰酸酯桥接网络表现出一定程度上可接受的生物相容性，如通过使用MTT测定的HeLa细胞的细胞活力测定所鉴定的，并且用作模型药物布洛芬（IBU）的体外药物递送的新基质。然而，这种具有25至144 m2 g-1的有限表面积的纳米级固体可以吸附约54 wt%的IBU（IBU/NOP-14质量比2：1，浸泡时间24 h），表明插入的药物的量不取决于表面积，而是与孔结构更密切相关。 IBU的释放行为取决于NOP-14的孔隙率和结构，用于宿主-药物相互作用，甚至优于其类似物PAF-6以及MCM-41。这项研究提供了通过优化反应条件来控制体内命运的可能性，并将药物的控释扩展到一般聚合物。
A novel set of nanoporous organic polytriazines with cyanate ester linkages, termed the NOP-14 series, have been designed and constructed from a new triangular monomer 2,4,6-tris(4-cyanatophenyl)-1,3,5-triazine. Four different concentrations of reactive groups in the same solvent medium, have been employed to allow an easy modulation of pore size. The cyanate ester-bridged networks demonstrates somewhat acceptable biocompatibility as identified by cell viability assays with HeLa cells using an MTT assay, and were used as new matrices for in vitro drug delivery of a model drug ibuprofen (IBU). This kind of nanoscale solid with limited surface areas ranging from 25 to 144 m2 g−1, however, can adsorb around 54 wt% of IBU (IBU/NOP-14 mass ratio 2 : 1, immersion time 24 h), demonstrating that the amount of inserted drug does not depend on the surface areas, but correlates more closely with the pore structure. The release behavior of IBU, depending on the porosities and structure of NOP-14 for host–drug interactions, is even better than that of its analogous PAF-6 as well as MCM-41. This study offers the possibility to facilely engineer pore structures through optimization of reaction conditions to control in vivo fate and also extends the controlled release of drugs to general polymers.