Effect of Repeated Treatment of Pregnant Women with Sulfadoxine-Pyrimethamine and Azithromycin on Preterm Delivery in Malawi: A Randomized Controlled Trial
Effect of Repeated Treatment of Pregnant Women with Sulfadoxine-Pyrimethamine and Azithromycin on Preterm Delivery in Malawi: A Randomized Controlled Trial
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DOI：
10.4269/ajtmh.2010.10-0264
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发表时间：
2010-12-01
影响因子：
3.3
通讯作者：
Ashorn, Per
中科院分区：
文献类型：
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作者：
Luntamo, Mari;Kulmala, Teija;Ashorn, Per
与怀孕期间感染有关的早产在撒哈拉以南非洲很常见。我们在马拉维招募了1，320名孕妇参加一项随机对照试验，以研究是否可以通过对母体疟疾和生殖道感染进行间歇性预防性治疗来降低早产和低出生体重（LBW）的发生率。参与者接受磺胺嘧啶-乙胺嘧啶（SP）两次（对照组），每月SP，或每月SP和两剂阿奇霉素（AZI-SP）。对照组早产发生率为17.9%，每月一次SP组为15.4%（P = 0.32），AZI-SP组为11.8%（危险比= 0.66，P = 0.01）。与对照组相比，AZI-SP组发生LBW的危险比为0.61（P = 0.02）。所有组中严重不良事件的发生率均较低。总之，早产和低出生体重的发生率在某些情况下可以减少治疗孕妇每月SP和两个阿奇霉素剂量。
Preterm delivery, which is associated with infections during pregnancy, is common in sub-Saharan Africa. We enrolled 1,320 pregnant women into a randomized, controlled trial in Malawi to study whether preterm delivery and low birth weight (LBW) incidence can be reduced by intermittent preventive treatment of maternal malaria and reproductive tract infections. The participants received either sulfadoxine-pyrimethamine (SP) twice (controls), monthly SP, or monthly SP and two doses of azithromycin (AZI-SP). The incidence of preterm delivery was 17.9% in controls, 15.4% in the monthly SP group (P = 0.32), and 11.8% in AZI-SP group (risk ratio = 0.66, P = 0.01). Compared with controls, those in AZI-SP group had a risk ratio of 0.61 (P = 0.02) for LBW. Incidence of serious adverse events was low in all groups. In conclusion, the incidence of preterm delivery and LBW can in some conditions be reduced by treating pregnant women with monthly SP and two azithromycin doses.