Suppression of aging in mice by the hormone Klotho
Suppression of aging in mice by the hormone Klotho
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DOI：
10.1126/science.1112766
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发表时间：
2005-09-16
期刊：
影响因子：
56.9
通讯作者：
Kuro-o, M
中科院分区：
文献类型：
--
作者：
Kurosu, H;Yamamoto, M;Kuro-o, M
小鼠Klotho基因表达的缺陷加速了多种年龄敏感性状的退化。在这里，我们表明Klotho在小鼠中的过表达延长了寿命。Klotho蛋白作为一种循环激素发挥作用，与细胞表面受体结合并抑制胰岛素和胰岛素样生长因子1（IGF 1）的细胞内信号，这是一种延长寿命的进化保守机制。通过干扰胰岛素和IGF1信号传导，观察到Klotho缺陷小鼠中衰老样表型的减轻，这表明Klotho介导的胰岛素和IGF1信号传导的抑制有助于其抗衰老特性。Klotho蛋白可能在哺乳动物中起抗衰老激素的作用。
A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals.