Celecoxib improves host defense through prostaglandin inhibition during Histoplasma capsulatum infection.
Celecoxib improves host defense through prostaglandin inhibition during Histoplasma capsulatum infection.
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塞来昔布在荚膜组织胞浆菌感染期间通过抑制前列腺素来改善宿主防御。
DOI：
10.1155/2013/950981
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发表时间：
2013
影响因子：
4.6
通讯作者：
Faccioli,LúciaHelena
中科院分区：
文献类型：
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作者：
Pereira,PriscillaAparecidaTartari;Trindade,BrunoCaetano;Secatto,Adriana;Nicolete,Roberto;Peres-Buzalaf,Camila;Ramos,SimoneGusmão;Sadikot,Ruxana;Bitencourt,ClaudiadaSilva;Faccioli,LúciaHelena
前列腺素作为炎症介质，类似于细胞因子，在先天性和适应性免疫应答期间作为免疫调节剂发挥作用。因此，我们使用药理学抑制剂塞来昔布，研究了C57 BL/6小鼠中野牡丹素在宿主防御荚膜组织胞浆菌感染中的作用。我们的研究结果表明，塞来昔布治疗抑制环氧合酶2，减少总的真菌负荷，并降低支气管肺泡腔和肺实质中的PGE 2，细胞因子，淋巴细胞，中性粒细胞和单核细胞的浓度。此外，塞来昔布治疗增加了一氧化氮、IFN-γ、LTB 4的合成和肺泡巨噬细胞的吞噬能力。此外，塞来昔布治疗增加了小鼠感染致命的H.荚膜这些结果表明，野牡丹素改变宿主的免疫反应，并在组织胞浆菌病的发病机制中发挥重要作用。因此，抑制木兰素可能是一种有价值的免疫调节策略和抗真菌治疗组织胞浆菌病的治疗。
Prostaglandins act as mediators of inflammation and, similar to cytokines, function as immune modulators during innate and adaptive immune responses. Therefore, using a pharmacological inhibitor, celecoxib, we investigated the role of prostaglandins in host defense againstHistoplasma capsulatuminfection in C57BL/6 mice. Our results showed that treatment with celecoxib inhibited cyclooxygenase 2, reduced the total fungal burden, and reduced the concentration of PGE2, cytokines, lymphocytes, neutrophils, and mononuclear cells in the bronchoalveolar space and lung parenchyma. In addition, celecoxib treatment increased the synthesis of nitric oxide, IFN‐γ, LTB4, and the phagocytic capacity of alveolar macrophages. Moreover, celecoxib treatment increased the survival of mice after infection with a lethal inoculum ofH. capsulatum. These results suggest that prostaglandins alter the host immune response and play an important role in the pathogenesis of histoplasmosis. Thus, the inhibition of prostaglandins could be a valuable immunomodulatory strategy and antifungal therapy for histoplasmosis treatment.