Bias in magnitude estimation following left hemisphere injury.
Bias in magnitude estimation following left hemisphere injury.
复制标题
左半球损伤后震级估计存在偏差。
DOI：
10.1016/j.neuropsychologia.2005.12.006
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发表时间：
2006
期刊：
影响因子：
2.6
通讯作者：
Murphy,Heather
中科院分区：
文献类型：
--
作者：
Woods,AdamJ;Mennemeier,Mark;Garcia-Rill,Edgar;Meythaler,Jay;Mark,VictorW;Jewel,GeorgeR;Murphy,Heather
人们越来越感兴趣的是确定大小估计的神经机制，以及确定可以解释单侧忽视等行为综合征的偏差形式。幅度估计与激活颞顶叶皮层在两个大脑半球的正常受试者，但是，目前还不清楚是否以及如何左半球病变偏见幅度估计，因为在这些科目的忽视和失语症的存在混淆检查的频率。与此相反，我们研究了幅度估计使用12种不同类型的感觉刺激，跨越5个感觉域的两个患者非常不同的临床表现后，单侧左半球中风。1例患者出现亚急性忽视，无失语症。另一个在颞顶叶损伤后有慢性失语症，但没有忽视。忽视患者在接受莫达非尼（Provigil）治疗后48小时重新检查觉醒减少。这两名患者表现出相对于正常受试者（n=83）的幅度估计偏倚。服用莫达非尼后，忽视患者的警觉性得到改善。他的忽视也解决了，他的震级估计更接近正常受试者。据我们所知，这是第一个证据，表明左半球损伤可以以类似但不完全相同的方式与右半球损伤相关的幅度估计产生偏差。
There is a growing interest both in identifying the neural mechanisms of magnitude estimation and in identifying forms of bias that can explain aspects of behavioral syndromes like unilateral neglect. Magnitude estimation is associated with activation of temporo-parietal cortex in both cerebral hemispheres of normal subjects; however, it is unclear if and how left hemisphere lesions bias magnitude estimation because the infrequency of neglect and the presence of aphasia in these subjects confound examination. In contrast, we examined magnitude estimation using 12 different types of sensory stimuli that spanned five sensory domains in two patients with very different clinical presentations following unilateral left hemisphere stroke. One patient had neglect sub-acutely without aphasia. The other had aphasia chronically after a temporo-parietal lesion but not neglect. The neglect patient was re-examined 48h after being treated with modafinil (Provigil) for decreased arousal. Both patients demonstrated bias in magnitude estimation relative to normal subjects (n=83). Alertness improved in the neglect patient after taking modafinil. His neglect also resolved and his magnitude estimates more closely resembled those of normal subjects. This is the first evidence, to our knowledge, that left hemisphere injury can bias magnitude estimation in a manner similar but not identical to that associated with right hemisphere injury.