Colonic glycoproteins in monozygotic twins with inflammatory bowel disease.
Colonic glycoproteins in monozygotic twins with inflammatory bowel disease.
复制标题
患有炎症性肠病的同卵双胞胎中的结肠糖蛋白。
DOI：
10.1016/0016-5085(91)90211-3
复制
发表时间：
1991
期刊：
影响因子：
29.4
通讯作者：
Järnerot,G
中科院分区：
文献类型：
--
作者：
Tysk,C;Riedesel,H;Lindberg,E;Panzini,B;Podolsky,D;Järnerot,G
采用离子交换色谱法对患有炎症性肠病的同卵双胞胎的结肠糖蛋白组成进行了评价。53个人，12对和1单双溃疡性结肠炎和14对克罗恩病，进行了评价。7对双胞胎在溃疡性结肠炎或克罗恩病的存在方面是一致的，而10个溃疡性结肠炎先证者和9个克罗恩病先证者的双胞胎兄弟姐妹不知道有炎症性肠病。与对照组（4030 ± 1，000 cpm/10，000 cpm总HCM）相比，溃疡性结肠炎患者（1040 ± 300 cpm/10，000 cpm总HCM）及其明显健康的双胞胎（1340 ± 540 cpm/10，000 cpm总HCM）中结肠粘蛋白的一种色谱定义组分（指定为HCM IV类）的含量降低。克罗恩病患者及其未受累双胞胎的粘蛋白组成与对照组无显著差异。这些观察结果表明，改变档案的粘蛋白糖蛋白可能存在于溃疡性结肠炎发病前，并可能是遗传定义。相反，似乎仅糖蛋白的改变不足以引发粘膜炎症。
Colonic glycoprotein composition was evaluated in monozygotic twins with inflammatory bowel disease using ion-exchange chromatography. Fifty-three individuals, 12 pairs and 1 single twin with ulcerative colitis and 14 pairs with Crohn's disease, were evaluated. Seven twin pairs were concordant for the presence of ulcerative colitis or Crohn's disease, whereas twin siblings of 10 ulcerative colitis probands and 9 Crohn's disease probands were not known to have inflammatory bowel disease. Content of one chromatographically defined component of colonic mucin, designated HCM species IV, was reduced in both patients with ulcerative colitis (1040 ± 300 cpm/10,000 cpm total HCM) and their apparently healthy twins (1340 ± 540 cpm/10,000 cpm total HCM) compared with control subjects (4030 ± 1,000 cpm/10,000 cpm total HCM). Composition of mucin in Crohn's disease patients and their nonaffected twins was not significantly different than in controls. These observations suggest that altered profiles of mucin glycoprotein may be present before the onset of ulcerative colitis and may be genetically defined. Conversely, it appears that alterations in glycoproteins only are not sufficient to initiate mucosal inflammation.