Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: the Cambridge Baby Growth Study
Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: the Cambridge Baby Growth Study
复制标题
DOI：
10.3945/ajcn.2008.27408
复制
发表时间：
2009-07-01
影响因子：
7.1
通讯作者：
Dunger, David B.
中科院分区：
文献类型：
--
作者：
Ong, Ken K.;Langkamp, Markus;Dunger, David B.
背景资料：配方奶喂养的婴儿比母乳喂养的婴儿表现出更快的生长速度和体重增加，并且他们有更高浓度的胰岛素样生长因子I（IGF-I）。目的：我们的目的是确定IGF-I浓度对出生后第一年体重、身长、体重指数（BMI）和肥胖的影响。设计：对675名3月龄和12月龄早产儿的953份毛细血管血样本进行了IGF-I浓度测定。这些婴儿出生于2002年至2008年之间的一个中心，并参加了前瞻性纵向出生队列。在0、3和12个月时测量体重、身长和4个皮褶厚度作为肥胖的指标。分析调整了年龄和sex.Results：婴儿配方奶粉喂养有较高的IGF-I浓度在3个月，他们表现出更大的体重，身高，体重指数，和肥胖之间的年龄3和12个月。3个月时的IGF-I浓度与随后的总体体重增加无关（P = 0.5）。然而，3月龄时较高的IGF-I浓度预示着随后的体长增加（配方奶喂养和母乳喂养的婴儿分别为P < 0.001和P = 0.007）和BMI增加较慢（分别为P < 0.001和P = 0.004）和肥胖（分别为P = 0.03和P = 0.003）。我们的研究结果支持IGF-I在婴儿体重增加与肥胖之间的比例关系。在配方奶喂养的婴儿中，较高的IGF-I浓度可能导致更快的身长增加;然而，其他机制可能解释了他们体重、BMI和肥胖的更快增加。美国临床营养杂志2009;90：156-61。
Background: Formula milk-fed infants show faster rates of growth and weight gain than do breastfed infants, and they have higher concentrations of insulin-like growth factor I (IGF-I).Objective: Our objective was to determine the influence of IGF-I concentrations on gains in weight, length, body mass index (BMI), and adiposity in the first year of life.Design: IGF-I concentrations were measured in 953 capillary blood samples from 675 unselected infants at ages 3 and 12 mo. These infants were born between 2002 and 2008 in one center and were participating in a prospective longitudinal birth cohort. Weight, length, and 4 skinfold thicknesses as an indicator of adiposity were measured at ages 0, 3, and 12 mo. Analyses were adjusted for age and sex.Results: Infants who were formula milk-fed had higher IGF-I concentrations at 3 mo, and they showed greater gains in weight, length, BMI, and adiposity between age 3 and 12 mo. IGF-I concentrations at 3 mo were unrelated to subsequent overall weight gain (P = 0.5). However, higher IGF-I concentrations at age 3 mo predicted greater subsequent gains in body length (P < 0.001 and P = 0.007 in formula milk-fed and breastfed infants, respectively) and slower gains in BMI (P < 0.001 and P = 0.004, respectively) and adiposity (P = 0.03 and P = 0.003, respectively).Conclusions: Our findings support a key role for IGF-I in the partitioning of overall infant weight gain into statural growth compared with adiposity. In formula milk-fed infants, higher IGF-I concentrations may lead to faster gains in length; however, other mechanisms likely explain their faster gains in weight, BMI, and adiposity. Am J Clin Nutr 2009;90:156-61.