The incidence of p53 mutations increases with progression of head and neck cancer.
The incidence of p53 mutations increases with progression of head and neck cancer.
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发表时间：
1993-10
期刊：
影响因子：
11.2
通讯作者：
Jay O. Boyle;J. Hakim;W. Koch;P. V. D. Riet;R. Hruban;R. Roa;Russell Correo;Y. Eby;J. Ruppert-J.-Rup
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作者：
Jay O. Boyle;J. Hakim;W. Koch;P. V. D. Riet;R. Hruban;R. Roa;Russell Correo;Y. Eby;J. Ruppert-J.-Rup
为了建立头颈部鳞状细胞癌进展的遗传模型，我们定义了这类癌症中p53突变的发生率和时间。我们对102例头颈部鳞状细胞癌病变的p53基因保守区进行了测序。其中原发性浸润性癌65例，非侵袭性档案标本37例，其中重度不典型增生13例，原位癌24例。P53基因突变在非侵袭性病变中的发生率为19%(7/37)，在浸润性癌中的发生率为43%(28/65)。这些数据表明，在原发性头颈部癌中，p53突变可以先于侵袭。此外，密码子热点谱与肺鳞癌相似，%的突变位于G核苷酸，提示烟草烟雾致癌物质参与了头颈部鳞癌的病因学。
To establish a genetic model of the progression of head and neck squamous carcinoma we have defined the incidence and timing of p53 mutations in this type of cancer. We sequenced the conserved regions of the p53 gene in 102 head and neck squamous carcinoma lesions. These included 65 primary invasive carcinomas and 37 noninvasive archival specimens consisting of 13 severe dysplasias and 24 carcinoma in situ lesions. The incidence of p53 mutations in noninvasive lesions was 19% (7/37) and increased to 43% (28/65) in invasive carcinomas. These data suggest that p53 mutations can precede invasion in primary head and neck cancer. Furthermore, the spectrum of codon hotspots is similar to that seen in squamous carcinoma of the lung and 64% of mutations are at G nucleotides, implicating carcinogens from tobacco smoke in the etiology of head and neck squamous carcinoma.