Restriction of T‐cell receptor repertoires in idiopathic CD4+ lymphocytopenia
Restriction of T‐cell receptor repertoires in idiopathic CD4+ lymphocytopenia
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特发性 CD4+ 淋巴细胞减少症中 T 细胞受体库的限制
DOI：
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发表时间：
2000
影响因子：
6.5
通讯作者：
L. Imberti
中科院分区：
文献类型：
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作者：
S. Signorini;S. Pirovano;S. Fiorentini;R. Stellini;Valeria Bianchi;A. Albertini;L. Imberti
我们报告了3例特发性CD 4+淋巴细胞减少症患者的α/β和γ/δ T细胞库，这些患者随着时间的推移表现出不同的临床表现和结局，并且受到高度限制。T细胞库的破坏不会影响感染的易感性：第一名患者无法获得对分枝杆菌的保护性反应，第二名患者显示临床改善，第三名患者没有发生机会性感染。这些结果表明，特发性CD 4+淋巴细胞减少症可引起单克隆/寡克隆T细胞扩增，但库紊乱的程度并不能指示疾病进展的严重程度。
We report that α/β and γ/δ T‐cell repertoires of three patients with idiopathic CD4+ lymphocytopenia, who showed different clinical manifestations and outcomes over time, were highly restricted. The disruption of T‐cell repertoires does not influence the susceptibility to infections: the first patient was unable to attain a protective response to mycobacterium, the second showed clinical improvement and the third did not develop opportunistic infections. These results indicate that idiopathic CD4+ lymphocytopenia could give rise to mono‐/oligoclonal T‐cell expansions, but the degree of repertoire disturbance is not indicative of the severity of disease progression.