Distribution and prognostic significance of QT intervals in the lowest half centile in 12,012 apparently healthy persons
Distribution and prognostic significance of QT intervals in the lowest half centile in 12,012 apparently healthy persons
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DOI：
10.1016/j.amjcard.2006.04.035
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发表时间：
2006-10-01
影响因子：
2.8
通讯作者：
Romeo, Francesco
中科院分区：
文献类型：
--
作者：
Gallagher, Mark Michael;Magliano, Giulia;Romeo, Francesco
在特发性室颤的幸存者和不明原因猝死者的近亲中发现了异常短的QT间期。大多数报告病例的心率校正QT（QTc）间期<300 ms。社区中此类值的流行率尚未记录。我们回顾了12，012名因职业原因接受常规体检的受试者的心电图（ECG）。所有病例均由2名医生测量QT间期，并计算QTc间期。QTc值最低5%的所有ECG均由2名QT分析专家进行审查，必要时校正QT测量值。关于后来生存的信息是从案件档案或公共记录中获得的。在最低1/2百分位数中，QTc值的分布继续遵循正常模式，没有证据表明存在明显的低值亚群。最短QTc为335 ms。QTc值最低1/2百分位数的60例受试者中有36例获得了后续生存信息。在ECG显示短QT间期后的7.9 +/-4.5年内，这些受试者均未死亡。总之，健康受试者的QTc间期：5330 ms极为罕见，QT间期在正常范围的最低1/2百分位数内并不意味着猝死的显著风险。(c)2006年爱思唯尔公司All rights reserved.
The presence of an abnormally short QT interval has been noted among survivors of idiopathic ventricular fibrillation and among close relatives of victims of unexplained sudden death. Most reported cases have had rate-corrected QT (QTc) intervals of < 300 ms. The prevalence of such values in the community has not been documented. We reviewed the electrocardiograms (ECGs) of 12,012 subjects who-underwent routine medical examinations for occupational reasons. The QT interval was measured by 2 physicians in all cases, and QTc interval was calculated. All ECGs with QTc values in the lowest 5% were reviewed by 2 cardiologists expert in QT analysis, and the QT measurement was corrected if necessary. Information about subsequent survival was obtained from the case file or from public records. In the lowest 1/2 centile, the distribution of QTc values continued to follow a normal pattern without evidence of a distinct subpopulation of low values. The shortest QTc encountered was 335 ms. Information about subsequent survival was available for 36 of the 60 subjects with the lowest 1/2 centile of QTc values. None of these subjects died during the 7.9 +/- 4.5 years subsequent to the ECG that demonstrated the short QT interval. In conclusion, a QTc interval of :5330 ms is extremely rare in healthy subjects, and the presence of a QT interval in the lowest 1/2 centile of the normal range does not imply a significant risk of sudden death. (c) 2006 Elsevier Inc. All rights reserved.