Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions.
Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions.
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作者：
Bazard P;Pineros J;Frisina RD;Bauer MA;Acosta AA;Paganella LR;Borakiewicz D;Thivierge M;Mannering FL;Zhu X;Ding B
体内炎症生物标志物水平的缓慢积累-也称为炎症-与无数与年龄相关的疾病有关。其中一些包括神经退行性疾病，如帕金森病，肥胖症，II型糖尿病，心血管疾病等。虽然还没有建立直接的相关性，但将年龄相关性听力损失（ARHL）-头号沟通障碍和我们老年人群中最普遍的神经退行性疾病之一-与炎症联系起来的研究引起了人们的兴趣。到目前为止，研究发现炎症标志物，如IL-6和白色血细胞，与人类和动物的ARHL有关。此外，研究离子通道和线粒体参与的研究表明，它们的功能和耳蜗炎症之间有着很好的关系。在这篇综述中，我们总结了听觉系统内炎症的关键发现，离子通道和线粒体功能的参与，最后讨论了随着年龄的增长控制炎症的潜在治疗方案。
The slow accumulation of inflammatory biomarker levels in the body—also known as inflammaging—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes, cardiovascular disease, and many others. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)—the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population—and inflammaging has gained interest. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Moreover, studies investigating ion channels and mitochondrial involvement have shown promising relationships between their functions and inflammaging in the cochlea. In this review, we summarize key findings in inflammaging within the auditory system, the involvement of ion channels and mitochondrial functions, and lastly discuss potential treatment options focusing on controlling inflammation as we age.
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