Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules
Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules
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DOI：
10.1039/c1cc14713g
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Hartinger, Christian G.
中科院分区：
文献类型：
--
作者：
Hanif, Muhammad;Nazarov, Alexey A.;Hartinger, Christian G.
制备了具有马来酰亚胺官能团的Ru-II(芳烃)抗癌化合物，以允许与含硫醇的生物分子选择性相互作用，从而强制将化合物选择性递送至肿瘤。
Ru-II(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.